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ChemicalBook Product Catalog Food Additives Nutrition supplements Vitamins Pyridoxine hydrochloride

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Pyridoxine hydrochloride NEW

$0.20 1000KG

$6.00 1KG

Min. Order1KG
Purity99%
Cas No58-56-0
Supply Abilityg-kg-tons, free sample is available
Update time2024-03-29

Henan Fengda Chemical Co., Ltd

1YR

China

Since2023-02-10

AddressRoom 01, 2288 E05, Building 14, East Henan University, Science and Technology Park, 279 Xisanhuan Ro

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Chemical Properties

Product Name	Pyridoxine hydrochloride
CAS No	58-56-0
EC-No
Min. Order	1KG
Purity	99%
Supply Ability	g-kg-tons, free sample is available
Release date	2024/03/29

1. Materials information

Names

Name	pyridoxine hydrochloride
Synonym	More Synonyms

Pyridoxine hydrochloride Biological Activity

Description	Pyridoxine hydrochloride (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.
Related Catalog	Signaling Pathways >> NF-κB >> Keap1-Nrf2 Research Areas >> Neurological Disease Natural Products >> Others
Target	Nrf2[1]
In Vitro	Pyridoxine exerts a protective potential against AD, attenuates ROS levels, decreases the expressions of cytoplasmic Nrf2, and upregulates whole-cell HO-1 expression[1].
References	[1]. Li C, et al. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway. Cell Mol Biol (Noisy-le-grand). 2018 Jul 30;64(10):119-124.

Chemical & Physical Properties

Boiling Point	491.9ºC at 760 mmHg
Melting Point	214-215 °C(lit.)
Molecular Formula	C8H12ClNO3
Molecular Weight	205.639
Flash Point	251.3ºC
Exact Mass	205.050568
PSA	73.58000
LogP	0.88220
Storage condition	2-8°C
Stability	Stable. Protect from air and light.
Water Solubility	0.1 g/mL (20 ºC)

MSDS

Pyridoxine hydrochloride MSDS(Chinese)

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UV1350000

CHEMICAL NAME :
Pyridoxol, hydrochloride

CAS REGISTRY NUMBER :
58-56-0

LAST UPDATED :
199712

DATA ITEMS CITED :
24

MOLECULAR FORMULA :
C8-H11-N-O3.Cl-H

MOLECULAR WEIGHT :
205.66

WISWESSER LINE NOTATION :
T6NJ B1 CQ D1Q E1Q &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
4 gm/kg

TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Subcutaneous

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
3 gm/kg

TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intravenous

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
530 mg/kg

TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
5500 mg/kg

TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Subcutaneous

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
2450 mg/kg

TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intravenous

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
660 mg/kg

TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Mammal - dog

DOSE/DURATION :
>500 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Mammal - cat

DOSE/DURATION :
1 gm/kg

TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intravenous

SPECIES OBSERVED :
Mammal - cat

DOSE/DURATION :
560 mg/kg

TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intramuscular

SPECIES OBSERVED :
Mammal - cat

DOSE/DURATION :
500 mg/kg

TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intravenous

SPECIES OBSERVED :
Rodent - rabbit

DOSE/DURATION :
464 mg/kg

TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intravenous

SPECIES OBSERVED :
Bird - pigeon

DOSE/DURATION :
145 mg/kg

TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Mammal - dog

DOSE/DURATION :
21400 mg/kg/15W-I

TOXIC EFFECTS :
Spinal Cord - demyelination Behavioral - changes in motor activity (specific assay) Behavioral - ataxia

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
2 mg/kg

SEX/DURATION :
female 38 week(s) after conception

TOXIC EFFECTS :
Reproductive - Maternal Effects - postpartum

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Intramuscular

DOSE :
2 mg/kg

SEX/DURATION :
female 38 week(s) after conception

TOXIC EFFECTS :
Reproductive - Maternal Effects - postpartum

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
8040 ug/kg

SEX/DURATION :
female 14 week(s) pre-mating - 12 day(s) post-birth

TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Effects on Newborn - biochemical and metabolic

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
4 gm/kg

SEX/DURATION :
female 6-15 day(s) after conception

TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Intraperitoneal

DOSE :
15 gm/kg

SEX/DURATION :
male 2 week(s) pre-mating

TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Intraperitoneal

DOSE :
7500 mg/kg

SEX/DURATION :
male 6 week(s) pre-mating

TOXIC EFFECTS :
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Intraperitoneal

DOSE :
15 gm/kg

SEX/DURATION :
male 6 week(s) pre-mating

TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange

TEST SYSTEM :
Human Lymphocyte

DOSE/DURATION :
2 mg/L

REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 124,175,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3950 No. of Facilities: 1955 (estimated) No. of Industries: 8 No. of Occupations: 39 No. of Employees: 57249 (estimated) No. of Female Employees: 35753 (estimated)

Safety Information

Symbol	GHS02, GHS06, GHS08
Signal Word	Danger
Hazard Statements	H225-H301 + H311 + H331-H370
Precautionary Statements	P210-P260-P280-P301 + P310-P311
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	UV1350000
HS Code	2936250000

Synthetic Route

Previous 1/8 Next

TRI-ACETYL PYRI...

10030-93-0

~96%

Pyridoxine hydr...

58-56-0

Literature: Geiger; Lalonde; Stoller; Schleich Helvetica Chimica Acta, 1984 , vol. 67, # 5 p. 1274 - 1282

Pyridoxamine di...

524-36-7

~25%

Pyridoxine hydr...

58-56-0

Literature: DSM IP ASSETS B.V. Patent: WO2006/66806 A1, 2006 ; Location in patent: Page/Page column 16 ;

N/A

90330-16-8

~76%

Pyridoxine hydr...

58-56-0

Literature: Shimada, Sadakatsu; Oki, Masaharu Chemical & Pharmaceutical Bulletin, 1984 , vol. 32, # 1 p. 38 - 43

Precursor & DownStream

Precursor 9	Previous 1/3 Next
CAS#:10030-93-0 TRI-ACETYL PYRI... CAS#:524-36-7 Pyridoxamine di... CAS#:4469-34-5 1,3-Dioxepin,4,... CAS#:24201-52-3 5-butoxy-4-meth...
DownStream 10	Previous 1/3 Next
CAS#:529-96-4 pyridoxamine ph... CAS#:94-75-7 2,4-Dichlorophe... CAS#:447-05-2 pyridoxine 5'-p... CAS#:948-00-5 3,3,8-trimethyl...

Customs

HS Code	2936250000
Summary	HS: 2936250000. (5-hydroxy-6-methylpyridine-3,4-diyl)dimethanol. VAT:17.0%. tax rebate rate:13.0%. supervision conditions:ab(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tarrif:4.0%. general tariff:20.0%

2. Packaging of materials

For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.

Or smaller package 1kg/bottle, 10kgs/bottle as request.

3. Shipping & Delivery

By Express

Provide door to door service

Suitable for goods under 50kg

Delivery: 3-7 days

Cost: low cost

By Air

Provide airport to airport service

Suitable for goods over 50kg

Delivery: 3-14 days

Cost: high cost

By Sea

Provide seaport to seaport service

Suitable for goods over 100kg

Delivery: 2-45 days

Cost: low cost

4. Contact information

For more details, pls contact us freely.

Email address: Tina@fdachem.com

Mob: 86 15225627621

WhatsApp/Skype/Wechat/LINE: 86 15225627621

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Company Profile Introduction

Henan Fengda Chemical Co., Ltd. is located in the High-tech Development Zone of Henan Province. Specializing in the production and sales of various fine chemical products required for industrial production, including chemical raw materials, organic raw materials, petrochemicals, chemical reagents, solvents, catalysts, and additives, etc.