Doramectin NEW

Doramectin is a new type of avermectin antiparasitic drug, whose deworming effect is similar to that of ivermectin, both of which can inhibit the transmission of nerve impulse between neuromuscles, causing the parasite to be paralyzed and die from the host. However, due to the high blood concentration of dolamectin in the body, the elimination is slower (the half-life of dolamectin is 5.7d, and the half-life of ivermectin is 4.2d). The maintenance time of the drug effect is prolonged, so the deworming effect is better, and there is no allergic reaction, and the use is safer.

Pharmacological action

Doramectin is used to treat ectoparasmic diseases such as nematodiasis and acariasis of domestic animals. It is produced by the fermentation of a new strain of Streptomycesavermitilis. The main difference between doramectin and ivermectin is that the C25 position is replaced by cyclohexyl, which is a novel, broad-spectrum anti-parasitic drug. It is highly effective against gastrointestinal nematodes, lungworms, eye worms, lice, ticks, mites and wound maggots, and has good repels against internal and external parasites, especially some nematodes (roundworms) and arthropods, but is ineffective against tapeworms, flukes and protozoa. Its mechanism of action is mainly to increase the release of the inhibitory transmitter gamma aminobutyric acid (GABA) in the insect body, thus blocking the transmission of nerve signals, so that muscle cells lose the ability to contract, and lead to the death of the insect body. The peripheral neurotransmitter of mammals is acetylcholine, which is not affected by dolamectin, which is not easy to cross the blood-brain barrier, has minimal damage to the central nervous system, and is relatively safe for livestock. The main characteristic is that the blood concentration and half-life are higher or twice longer than ivermectin. The United States has approved the injection for cattle and pigs and the pouring agent for cattle.

Matters needing attention

1, the nature of doramectin is not stable, rapidly decomposes and inactivates under sunlight, and its remaining drugs are toxic to fish and aquatic organisms, so pay attention to water source protection.

2, pouring agent: After cattle application, can not rain within 6 hours.

3. Beware of dogs.

4. Keep the product out of reach of children. The operator should not eat or smoke while using the product. Wash hands after operation.

5, its remaining drugs are toxic to fish and aquatic organisms, and attention should be paid to protecting water resources.

6, the drug period, cattle 35 days, pig 24 days.