Basic Information
CAS No:171596-29-5
Molecular Formula:C22H19N3O4
Molecular Weight: 389.4
Appearance: White powder
Cialis Chemical Properties
Item | Specifications |
---|
Appearance | white powder |
Purity/% | 99.1% |
Density b(20℃)(kg/m3) | 1500 |
Flow viscosity(20℃)(mm2/s) | 1.700-1.800 |
Flashpoint/℃ | ≥364.5 |
PSA | 74.87 |
Refractive index | 1.758 |
solubility | Soluble in: dimethylformamide |
Copper corrosion(50℃,3h)/Grade | ≤1 |
Mechanical impurities | NO |
Cialis USES
Tadalafil
is a PDE5 inhibitor with an IC50 value of 1.8 nM.IC50 Value: 1.8±0.4nM
[1]Target: PDE 5Tadalafil is marketed in pill form for treating erectile
dysfunction(ED) under the name Cialis, and under the name Adcirca for
the treatment of pulmonary arterial hypertension. Tadalafil can elevate
the level of cGMP in the corpus cavernosum and effectively improve ED of
various causes and degrees.in vitro: Biochemical potencies (affinities)
of these compounds for PDE5 determined by IC(50), K(D) (isotherm), K(D)
(dissociation rate), and K(D) ((1/2) EC(50)), respectively, were the
following: sildenafil (3.7 +/- 1.4, 4.8 +/- 0.80, 3.7 +/- 0.29, and 11.7
+/- 0.70 nM), tadalafil (1.8 +/- 0.40, 2.4 +/- 0.60, 1.9 +/- 0.37, and
2.7 +/- 0.25 nM); and vardenafil (0.091 +/- 0.031, 0.38 +/- 0.07, 0.27
+/- 0.01, and 0.42 +/- 0.10 nM). Thus, absolute potency values were
similar for each inhibitor, and relative potencies were vardenafil
>> tadalafil > sildenafil [1]. 0.5 ml tadalafil solutions with
different concentrations were added (0.2, 0.1, 0.05 and 0.025 μg ml-1,
respectively) into semen samples. In both groups, samples treated with
0.2 μg ml-1 tadalafil had significant increase in sperm motility after 2
h incubation [2].in vivo: The Tadalafil-treated group showed enhanced
erectile function (intracavernosal pressure/mean arterial pressure) at
0.3, 0.5, 1, 3, and 5 Hz compared with diabetic group values at the
respective frequencies (P <.05) that approached control values [3].
oral administration of tadalafil (20 mg) or sildenafil (100 mg) was
given. In both groups, computer-assisted semen analysis parameters
showed no significant difference. After the administration of tadalafil
(2 h) and sildenafil (1 h), there was no significant difference observed
in premature acrosome reaction incidence rate [2].Clinical trial: Study
the Safety and Effectiveness of Tadalafil in Men With Problems Getting
or Maintaining an Erection When Taken Prior to Desiring an Erection.
Phase 3
Cialis Packaging
Packing: 195KG/Drum
Belonging to common goods
Cialis Storage
1. Stored in a cool dry place away from direct sunlight and water
2. Separated from oxidants and foodstuffs
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