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Paricalcitol

$ 0.01 /1KG

Min. Order1KG
Purity98%； 99%
Cas No131918-61-1
Supply Ability1kg; 5kg; 10kg；25kg
Update time2020-01-08

career henan chemical co

5YR

China

Chemical Properties

Product Name	Paricalcitol
CAS No	131918-61-1
EC-No
Min. Order	1KG
Purity	98%； 99%
Supply Ability	1kg; 5kg; 10kg；25kg
Release date	2020/01/08

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Product Name:

Paricalcitol

Synonyms:

PARICALCITOL (10 MG)F0E3030.997MG/MG(AI);PARICALCITOL;19-nor-1alpha,25-dihydroxyvitamin D2;(1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-6-Hydroxy-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]cyclohexane-1,3-diol;Zemplar;1,3-Cyclohexanediol, 5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,2E,4S)-5-hydroxy-1,4,5-trimethyl-2-hexen-1-yl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,3R,5Z)-;Paricalcitol (10 mg) (COLD SHIPMENT REQUIRED);(1R,3R,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-Octahydro-1-[(1R,2E,4S)-5-hydroxy-1,4,5-triMethyl-2-hexen-1-yl]-7a-Methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol

CAS:

131918-61-1

MF:

C27H44O3

MW:

416.64

EINECS:

658-064-6

Product Categories:

-;Vitamin D3 analogs;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals

Mol File:

131918-61-1.mol

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Paricalcitol Chemical Properties

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Boiling point

564.8±50.0 °C(Predicted)

density

1.121±0.06 g/cm3(Predicted)

14℃

pka

14.34±0.40(Predicted)

form

neat

InChIKey

BPKAHTKRCLCHEA-UBFJEZKGSA-N

CAS DataBase Reference

131918-61-1(CAS DataBase Reference)

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Safety Information

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RIDADR

UN1170 - class 3 - PG 2 - Ethanol, solution

HS Code

2936299055

Hazardous Substances Data

131918-61-1(Hazardous Substances Data)

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MSDS Information

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Paricalcitol Usage And Synthesis

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Description

Paricalcitol was launched as Zemplar in the US for the prevention and treatment of secondary hyperthyroidism associated with chronic renal failure. Paricalcitol is a synthetic vitamin D2, namely a novel 1-alpha-hydroxy-19-noranalogue in which the ring A exocyclic methylene group, typical of all vitamin D systems, has been replaced by two hydrogen atoms. Paricalcitol is the first vitamin D analogue marketed for this indication. In patients with chronic renal failure, Paricalcitol appreciably reduced levels of parathyroid hormone (PTH) without a significant difference in the incidence rate for hypercalcemia or hyperphosphatemia when compared with placebo.

Chemical Properties

White Solid

Originator

Abbott (US)

Uses

Synthetic analog of vitamin D. Antihyperparathyroid.

Uses

Antihyperparathyriod

Uses

1,25-Dihydroxy vitamin D2 is a potent agonist of the vitamin D receptor. Paricalcitol is a synthetic 1,25-dihydroxy vitamin D2 analog. As vitamin D deficiency, associated with chronic kidney disease, leads to an increase in parathyroid hormone (secondary hyperparathyroidism), paricalcitol is used in renal patients to block parathyroid hormone overproduction. Vitamin D deficiency is also a risk factor in cancer, cardiovascular disease, hypertension, and diabetes, and paricalcitol may have applications in those contexts as well.

Brand name

Zemplar (Abbott).

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