AZD-8055

$ 2.00 /1kg

Min. Order1kg
Purity99%
Cas No1009298-09-2
Supply Ability100kg
Update time2019-07-06

career henan chemical co

6YR

China

Chemical Properties

Product Name	AZD-8055
CAS No	1009298-09-2
EC-No
Min. Order	1kg
Purity	99%
Supply Ability	100kg
Release date	2019/07/06

AZD-8055 Basic information

Product Name:	AZD-8055
Synonyms:	AZD 8055 [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol;AZD8055, >=98%;AZD-8055;[5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol;Propanoic acid, 2,2-dimethyl-, [5-(2,4-dichloropyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl]methyl ester;(5-{2,4-dichloropyrido[2,3-d]pyriMidin-7-yl}-2-Methoxyphenyl)Methyl 2,2-diMethylpropanoate;[5-[2,4-Bis((3S)-3-MethylMorpholin-4-yl)pyrido[;5-[2,4-Bis[(3S)-3-Methyl-4-Morpholinyl]pyrido[2,3-d]pyriMidin-7-yl]-2-MethoxybenzeneMethanol
CAS:	1009298-09-2
MF:	C25H31N5O4
MW:	465.54474
EINECS:	-0
Product Categories:	Inhibitors;Akt;mTOR;PI3K;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Protein Kinase Inhibitors and Activators;PI3K/Akt/mTOR
Mol File:	1009298-09-2.mol

AZD-8055 Chemical Properties

density

1.248

Safety Information

Safety Statements

24/25

MSDS Information

AZD-8055 Usage And Synthesis

Uses

A novel ATP-competitive inhibitor of mTOR with an IC50 of 0.8 nM.

Uses

A potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM. It inhibits the phosphorylation of mTORC1 substrates p70S6K and 4E-BP1 as well as phosphoryla tion of the mTORC2 substrate AKT and downstream proteins. The rapamycin-resistant T37/46 phosphorylation sites on 4E-BP1 were fully inhibited by AZD8055, resulting in significant inhibition of cap-dep endent translation. In vitro, AZD8055 potently inhibits proliferation and induces autophagy in H838 and A549 cells. In vivo, AZD8055 induces a dose-dependent pharmacodynamic effect on phosphorylated S 6 and phosphorylated AKT at plasma concentrations leading to tumor growth inhibition.

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