Main role:
5-aminolevulinic acid hydrochloride is mainly used as a substrate for 5-aminolevulinic acid dehydrogenase, biochemical research.
Usage:
5-aminolevulinic acid hydrochloride is a natural amino acid; As a precursor of tetrapyrrole for chlorophyll and heme biosynthesis; Antitumor agents (photosensitizers).
In vitro studies:
5-aminolevulinic acid (5-ALA) -Photodynamic therapy (PDT) leads to downregulation of nuclear factor κB (NFkappaB) and baculoviruses containing inhibitors of -3 (BIRC-3) protein duplication. 5-Aminolevulinicacid (5-ALA) -Photodynamic therapy (PDT) leads to increased Bax expression: Bcl-2 ratio and mitochondrial release of cytochrome c and apoptosis-inducing factor (AIF). 5-aminolevulinic acid leads to metal-catalyzed oxidation of reactive oxygen species, leading to damage of rat liver mitochondria and DNA damage in vivo and in vitro.
5- Aminolevulinicacid dose-dependent induced nuclear and mitochondrial DNA damage in human SVNF fibroblasts and rat PC12 cells. 5-aminolevulinic acid reduced cAMP levels in a dose-dependent way (maximum inhibition was 38% at 1mM) due to inhibition of basaladenylate cyclase activity. 5-Aminolevulinicacid also inhibits adenylate cyclase activity stimulated by fluoride- and Gpp(NH)p, but not by forskolin. 5-aminolevulinic acid also inhibited adenylate cyclase activity in the rat cortex and in the membrane separated from the striatum and human cortex.
5-aminolevulinic acid (0-3 mm) dose-dependent inhibition of glutamate uptake by astrocytes. 5-Aminolevulinicacid significantly reduces glutamate uptake of K (m) and V(max), indicating non-competitive inhibition. In cultured astrocytes under these conditions, 5-aminolevulinic acid significantly increased lipid peroxidation in astrocytes. 5-Aminolevulinicacid mediated sonodynamic therapy demonstrated synergistic apoptotic effects in THP-1 macrophages, involving excessive intracellular reactive oxygen species production and MMP loss.
Melting Point
| ~150 °C |
Flashing Point
| 155-157°C |
Storage Condition
| -20°C |
| Solubility | H2O:50 mg/mL |
| PH | pH (10g/l, 25℃) : 2.5～3.0 |
| Water Solubility | Soluble in dimethyl sulfoxide, methanol and water. |
| Decomposition | 155-157 ºC |
| Merck | 14,446 |
Our advantages:
1) Timely communication, reply within 12 hours.You can leave any messages on our whatsapp or send email to us.
2)Selecting raw materials strictly,our products are the highest purity.
3)Reasonable and competitive price.
4) Free sample for your evaluation.Customers only need to undertake the shipping fee for delivery the samples to your destionation.
5)OEM/ODM Available.Trial order is available for testing after samples.
6) Packaging can be customized according to each buyers' special request.
We guarantee that your package will pass 100% through the Mexico US, UK, Australia, Netherlands, Canada, France, Germany, Spain, Belgium, Sweden, Poland, Russian, Ukraine, Kazakhstan, Czech Republic, Slovakia, Portugal.
We have freight forwarders in these countries, and our customs clearance company will clear your parcels without any customs issues, sometimes even 1000 kg. Door to door service. Make sure you receive 100% of the goods. Let you have a good experience of our strong freight capacity.
Company Introduction
hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and development production of reagent tens of thousands of species. our aim is quality strives for the survival. Seek development by credit reputation. Our products have big price advantage in Europe South America and so on .and Our company also has the advantage of high quality in Africa. in the past two years our products has reached more than 30 countries in the world, Europe. South America. North America, southeast Asia, Africa, etc. We welcome all over the world with the best quality and lowest price friend common cooperation and common development!
After Sales Service
1) Best quality in your requirement
2)Competitive price in china market
3)Mature technical support
4)Professional logistic support
5 )Full experience of large numberscontainers loading in chinese sea port
6 )Fast shipment by reputed shipping line
7) Packing with pallet as buyer's special request
8) Best service after shipment.
9) Cargoes together with container after-sales service available
10) Full experience in export
11)Raw materials from chinese origin
FAQ
What is the way you ship?
Express: FedEx, UPS, EMS, DHL, USPS, TNT, DPD, Aramex etc
Our way of shipping the products is universal and secure.
The company name and other contents related to pharmacy are not written on the package slips.
The way of packing is regularly changed for a secure delivery.
The packages are small in order to avoid unwelcomed questions . If the order is big, then it will be divided into two or more packages
Can the packages be trackable?
YES, we provide tracking number and you can track on internet.
Where do you ship to?
Worldwide.
Do you offer domestic shipping/remail shipping?
Yes we can ship to USA/UK/Canada/Australia/Germany etc warehouse first then to you.
Do you ensure your packing , what about customs, what happens if the package is retained?
We concern a lot about our safety system, we pack the orders as secure as possible. If a package is seized at customs, reships of seized orders will be done provided you have a copy of the letter to show us. If you receive a seizure letter, please contact us immediately with a scanned copy of the seizure letter, and also a new address to have your order reshipped to.
Which payment options are available?
Bitcoin
Western Union
Bank wire
MoneyGram
China
