| Product Name | IXABEPILONE |
| Synonyms | XABEPILONE;(1R,5S,6S,7R,10S,14S,16S)-6,10-dihydroxy-1,5,7,9,9-pentamethyl-14-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-1Chemicalbook7-oxa-13-azabicyclo[14.1.0]heptadecane-8,12-dione;Aza-epothiloneB;Bms247550-1;Ixempra;Ixemprakit;Unii-K27005np0a;Azi-epothiloneB |
| MOQ | 1kg |
| CAS | 219989-84-1 |
| Appearance | White |
| Molecular Formula | C27H42N2O5S |
| Molecular Weight | 506.7 |
| Assay | >99% |
| Application | For research purpose only |
| Packing | 25kg/drum |
| Storage | Store in a well-closed,light-resistant container |
| Remarks | NA |
| Custom synthesis | Available |
Ixabepilone (Ixempra) is a novel anti-tumor chemotherapy drug that mimics the polymerization of paclitaxel tubulin and inhibits the depolymerization of epothilones. In October 2007, the FDA approved Ixempra alone or in combination with capecitabine for the treatment of metastatic or locally advanced breast cancer that has not responded to anthracycline, taxane derivatives, or capecitabine therapy. Epothilones: Ixabepilone (BMS-247550) is a semi-synthetic analogue of Epothilone β lactam, which is a class of 16-membered macrolides first isolated from Sorangiumcellulosum species by Holfe and Reichenbach in 1992. It is a new generation of anti-mitotic drugs, and its mechanism of action is similar to taxanes, which can bind to tubulin and cause cancer cells to fail to undergo mitosis smoothly, thus leading to apoptosis of cancer cells. It is superior to paclitaxel in terms of anti-tumor spectrum, anti-tumor activity, safety, water solubility and synthesis method. Ishapilone is the first ebomycin class of novel antitumor drugs, which can bind to tubulin and cause cancer cells to fail to undergo mitosis and ultimately lead to apoptosis of tumor cells. Ishapilon has a new chemical structure and different microtubule binding sites with taxus, so it has stronger anti-tumor activity. Moreover, ishapilon has a low susceptibility to tumor resistance mechanisms.
Packaging & Shipping
| Quantity(Metric Tons) | 1 - 1 | 2 - 20 | >20 |
| Est. Time(days) | 10 | 25 | To be negotiated |
Company Information
Hebei Lingding Biotechnology Co., Ltd. is a professional business company ,that include pharmaceutical raw materials, pharmaceutical intermediates,and other more than 1000 products of the enterprise, The registered capital is 3 million yuan, it is a collection of scientific research, production and sales in one of the enterprises.
Since its establishment, the company has always adhered to the core concept of "focus on products, attentive service", adhere to the business purpose of "innovation, professional, win-win", to provide customers with a full range of meticulous and thoughtful services. We will adhere to the customer's serious and responsible attitude, comply with the standardized operation procedures, with efficient execution to complete customer needs.
The company's products are sold all over the world, mainly exported to the United States, Europe, Southeast Asia, Australia, the Middle East and South Africa and other countries.The company has a strong scientific research and technical team, can provide customers with high quality products and a full range of services. We will provide first-class products and better service to face the needs of customers, to meet the challenges of the market. Welcome domestic and foreign customers to negotiate.
Our Services
1.Any inquiry or message will be replied within 12 hours.
2.Professional manufacturer. Welcome to visit our website.
3.API, Intermediate are available, we can offer Custom Synthesis, and registration as well.
4.Fast delivery.
5.After-sale services
FAQ
Q1. Are you a manufacturer?
Answer: Yes, we have our own factory.
Q2. Do you have GMP or DMF?
Answer: Yes, we have GMP certificate for some products, and we can provide DMF as well.
Q3. What information should I let you know if I want to get a quotation?
Answer: -Quality you require, eg. Assay, Purity, or single impurity
-Quantity you need
-Standard you want, such as USP, EP, JP etc.
Q4. How to make the payment?
Answer: T/T in advance are highly recommended. We can accept Western Union,
Money Gram and Paypal as well.
Q5. When will you deliver the goods?
Answer: For sample(less than 1kg), in about 3 working days after payment; for larger orders (more than 1kg), in about 7 working days after payment.
Q6. How will you deliver the goods?
Answer: We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS, China Air Post. For container products, we can do sea shipping. You also can choose your own shipping forwarder.
Q7. When will we receive the goods?
Answer: For samples, we will send by TNT/DHL/FEDEX/UPS express, usually it takes about 3-5 to reach you; for larger orders, it will take about 7 -10days at most.
Q8. What if we find your products unsatisfied?
Answer: We will send you a COA (Certificate of Analysis) to you first for you to confirm the quality, but if you find our products not confirm with the COA after you receive it, please show us your test result, we will refund you once we confirm that.
Q9.Do you have stock?
Answer:As we know,most customers prefer stock,so we will try to keep stock for some products.
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