Hypromellose (Hypromellose), also known as hypromellose, is one of the non-ionic cellulose mixed ethers. It is a semi-synthetic, inactive, viscoelastic polymer, often used as a lubricant in ophthalmology, or as an excipient or excipient in oral medicine.
Appearance: white or almost white fibrous or granular powder
Stability: The solid is flammable and incompatible with strong oxidants.
Granularity: 100 mesh pass rate is greater than 98.5%; 80 mesh pass rate is 100%. Special specifications have a particle size of 40-60 mesh.
Carbonization temperature: 280-300℃
Apparent density: 0.25-0.70g/cm3 (usually around 0.5g/cm3), specific gravity 1.26-1.31.
Discoloration temperature: 190-200℃
Surface tension: 42-56dyne/cm for 2% aqueous solution
Solubility: soluble in water and some solvents, such as ethanol/water, propanol/water in appropriate proportions. The aqueous solution has surface activity. High transparency and stable performance. Different specifications of products have different gel temperatures, and solubility changes with viscosity. The lower the viscosity, the greater the solubility. Different specifications of HPMC have different performances. The dissolution of HPMC in water is not affected by pH.
With the decrease of methoxy group content, the gel point of HPMC increases, the water solubility decreases, and the surface activity also decreases.
HPMC also has the characteristics of thickening ability, salt resistance, low ash powder, pH stability, water retention, dimensional stability, excellent film-forming properties, and a wide range of enzyme resistance, dispersibility and adhesion.
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