11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride NEW

$ 30.00 /1kg

Min. Order1kg
Purity98%
Cas No111974-74-4
Supply Ability2000kg
Update time2024-04-30

hebei hongtan Biotechnology Co., Ltd

1YR

China

Chemical Properties

Product Name	11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride
CAS No	111974-74-4
EC-No
Min. Order	1kg
Purity	98%
Supply Ability	2000kg
Release date	2024/04/30

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Chemical Properties

Melting point	180-184°C
storage temp.	Inert atmosphere,2-8°C
solubility	Soluble in DMSO, Methanol, Distilled Water
form	solid
color	Off-white
Stability:	Stable for 1 year from date of purchase as supplied. Solutions in DMSO, methanol, or distilled water may be stored at -20°C for up to 3 months.
InChI	InChI=1S/C17H17N3S.ClH/c1-3-7-15-13(5-1)17(20-11-9-18-10-12-20)19-14-6-2-4-8-16(14)21-15;/h1-8,18H,9-12H2;1H
InChIKey	MJPARFLICDXWJT-UHFFFAOYSA-N
SMILES	C1(N2CCNCC2)=NC2C=CC=CC=2SC2=CC=CC=C12.Cl
CAS DataBase Reference	111974-74-4(CAS DataBase Reference)

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Usage And Synthesis

Description	Norquetiapine 2HCl (111974-74-4) is a pharmacologically active metabolite of quetiapine (Seroquel).1? Exhibits distinct pharmacological activity from quetiapine and plays an important role in its antidepressant activity.2? Activates ERK1/2 and induces release of BDNF in C6 glioma cells which may contribute to the antidepressant properties of quetiapine.3?Inhibits the norepinephrine transporter which may contribute to the antipsychotic activity of quetiapine.4
Chemical Properties	11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride is Pale-Yellow Solid
Uses	11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride is a metabolite of Quetiapine, a Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties used as an antipsychotic
Uses	N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride (Quetiapine EP Impurity B) is a metabolite of Quetiapine, a Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties used as an antipsychotic.
References	1) Altamura?et al.?(2012),?Effect of quetiapine and norquetiapine on anxiety and depression in major psychoses using a pharmacokinetic approach: a prospective observational study; Clin. Drug Investig.,?32?213 2) Lopez Munoz and Alamo (2013),?Active metabolites as antidepressant drugs: the role of norquetiapine in the mechanism of action of quetiapine in the treatment of mood disorders; Front. Psychiatry,?4?102 3) Di. Benedetto?et al.?(2012),?N-desalkylquetiapine activates ERK1/2 to induce GDNF release in C6 glioma cells: a putative cellular mechanism for quetiapine as antidepressant; Neuropharmacology,?62?209 4) Bjorkholm?et al.?(2013),?Role of concomitant inhibition of the norepinephrine transporter for the antipsychotic effect of quetiapine; Eur. Neuropsychopharmacol.,?23?709

Packing &shipping&Payment

Packing:25kg/drum
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :

Quantity(Kilograms)	1 - 10000	>10000
Est. Time(days)	5	To be negotiated

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11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride NEW

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