1. Materials information
Names
| Name | polysorbate 20 |
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| Synonym | More Synonyms |
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Tween 20 Biological Activity
| Description | Polysorbate 20 is a polyoxyethylene (POE)-type nonionic surfactant[1][2][3]. |
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| Related Catalog | Research Areas >> Others Signaling Pathways >> Others >> Others |
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| In Vitro | Addition of Polysorbate 20 can modify lignin surface properties to change its hydrophobicity, hydrogen bonding ability and surface charges, thus reducing the non-productive adsorption of proteins[1]. Polysorbate 20 (0.35%-0.7% w/w) added to 0.05 mol/L of phosphate buffer pH 6.5 dramatically increased the apparent solubility of the drug from 0.8 μg/ml even to 353 μg/ml, while its effect in lower pH or in water was much smaller (20 μg/ml in pH 4.5). The increased concentration of phosphate salts (0.2 mol/l) at pH 6.5 in the presence of 0.7% of polysorbate 20, resulted in further increase of candesartan cilexetil solubility to 620 μg/ml[2]. |
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| References | [1]. Yu-An Chen, et al. Evaluation of the action of Tween 20 non-ionic surfactant during enzymatic hydrolysis of lignocellulose: Pretreatment, hydrolysis conditions and lignin structure. Bioresour Technol. 2018 Dec;269:329-338. [2]. Katarzyna Hoppe, et al. The effect of polysorbate 20 on solubility and stability of candesartan cilexetil in dissolution media. AAPS PharmSciTech. 2014 Oct;15(5):1116-25. [3]. JustynaŁuczak, et al. Micelle formation of Tween 20 nonionic surfactant in imidazolium ionic liquids. Colloids and Surfaces A: Physicochemical and Engineering Aspects. Volume 471, 20 April 2015, Pages 26-37. |
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Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
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| Boiling Point | 695.8±55.0 °C at 760 mmHg |
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| Molecular Formula | C26H50O10 |
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| Molecular Weight | 604.813 |
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| Flash Point | 207.1±25.0 °C |
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| Exact Mass | 604.418640 |
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| PSA | 133.14000 |
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| LogP | 5.37 |
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| Vapour Pressure | 0.0±5.0 mmHg at 25°C |
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| Index of Refraction | 1.502 |
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| Storage condition | 0-6°C |
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| Stability | Stable. Incompatible with strong oxidizing agents. |
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| Water Solubility | 100 g/L | 100 g/L |
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2. Packaging of materials
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping & Delivery
Provide door to door service
Suitable for goods under 50kg
Delivery: 3-7 days
Cost: low cost
Provide airport to airport service
Suitable for goods over 50kg
Delivery: 3-14 days
Cost: high cost
Provide seaport to seaport service
Suitable for goods over 100kg
Delivery: 2-45 days
Cost: low cost
4. Contact information
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