(S)-3-アミノ-2-(tert-ブトキシカルボニルアミノ)プロピオン酸

外観

白色～微黄色、結晶性粉末～粉末

用途

有機合成原料。

化学的特性

White powder

使用

Reactant for:

• Protein assembly directed by synthetic molecular recognition motifs
• Solid phase synthesis of gramicidin S cyclic analogs with antibiotic and hemolytic activities
• Synthesis of HCV protease inhibitor modified analogs
• Solid phase synthesis of peptidic V1a receptor agonists
• Directed peptide assembly at lipid-water interface

定義

Boc-Dap-OH is an amino acid molecule that is a zwitterion. Therefore, the addition of a base is required to prepare a nucleophilic amino acid. It is commonly acts as a nucleophile to attack the acyl carbon.

製造方法

The raw material was dissolved inabsolute ethanol (5 mL), and the reaction flask was immersed in a water bath at 25 C. To the alcoholicsolution, 10% palladium-carbon (22.9 mg) and 1,4-cyclohexadiene (10 equivalents with respect to4; 0.47 mL, 5.0 mmol) were added, and the mixture was allowed to react under magnetic stirringovernight. After filtration over a short pad of Celite 545, the solvent was evaporated under reducedpressure conditions, and the solid residue was partitioned in a 1:1 (v/v) H2O/EtOAc mixture (10 mL).The aqueous phase was separated, back extracted with EtOAc (3 10 mL), concentrated under reducedpressure conditions, and lyophilized.Finally, the target product Boc-Dap-OH is obtained.