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外観
白色~わずかにうすい褐色、結晶又は粒状
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定義
本品は、次の化学式で表されるアミンの塩酸塩である。
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溶解性
水及びエタノールに溶ける。
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化粧品の成分用途
パーマネント.ウェーブ用還元剤、還元剤
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効能
尿路結石治療薬 (システイン結石), シスチン症治療薬
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使用上の注意
アルゴン封入
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説明
Cysteamine is a stable aminothiol with radioprotective activities. It reduces ionizing radiation-induced death and chromosomal damage in mice in a dose-dependent manner. Cysteamine binds rapidly and temporarily to plasma proteins upon administration and this activity is directly correlated to its radioprotective effects. In vitro, 0.1 mM cysteamine depletes 90% of free cystine from cystinotic fibroblasts. Formulations containing cysteamine have been used to treat nephropathic cystinosis and reduce glomerular deterioration in humans.
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化学的特性
White Solid
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使用
Cysteamine hydrochloride is used as an antioxidant and in radiation therapy.
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一般的な説明
Cysteamine is an aminothiol that can reduce important oxidized disulfide molecules such as cystine to yield cysteine.
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危険性
Toxic by inhalation and ingestion.
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合成
In particular to synthesizing cysteamine hydrochloride in alkali surroundings, which is characterized in that ethanolamine solution and sulfate solution are used as raw material; 2- amino ethyl sulfate is firstly synthesized before made into ring in alkaline solution by 2-amino ethyl sulfate and carbon disulfide, thereby getting Alpha -mercaptothiazoline; alkaline hydrolysis is made upon Alpha -mercaptothiazoline to produce cysteamine hydrochloride.
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純化方法
Purify the salt by recrystallisation from EtOH. It is freely soluble in H2O and should be stored in a dry atmosphere. [Mills & Bogert J Am Chem Soc 62 1177 1940.] The picrate has m 125-126o; see previous entry for free base. [Beilstein 4 IV 1570.]