ポリ(1-ビニルピロリドン-co-酢酸ビニル) (コポリマー, 7:3) (50%エタノール溶液)

外観

無色～うすい黄赤色～黄色透明液体

定義

本品は、ビニルピロリドン(VP)と酢酸ビニル(VA)との共重合体である。

化粧品の成分用途

ヘアスタイリング剤、非活性剤系分散剤、結合剤、皮膜形成剤

化学的特性

white powder

使用

Poly(1-vinylpyrrolidone-co-vinyl acetate)

調製方法

Copovidone is manufactured by free-radical polymerization of vinylpyrrolidone and vinyl acetate in a ratio of 6 : 4. The synthesis is conducted in an organic solvent owing to the insolubility of vinyl acetate in water.

一般的な説明

～1:2.4 mole ratio of VP:VA

応用例（製薬）

Copovidone is used as a tablet binder, a film-former, and as part of the matrix material used in controlled-release formulations. In tableting, copovidone can be used as a binder for direct compression and as a binder in wet granulation. Copovidone is often added to coating solutions as a film-forming agent. It provides good adhesion, elasticity, and hardness, and can be used as a moisture barrier.

安全性プロファイル

Moderately toxic by ingestion.Combustible, especially in powdered form. Incompatiblewith strong oxidising agents, strong reducing agents. Whenheated to decomposition it emits toxic vapors of NOx.

安全性

Copovidone is used widely in pharmaceutical formulations and is generally regarded as nontoxic. However, it is moderately toxic by ingestion, producing gastric disturbances. It has no irritating or sensitizing effects on the skin. A study was conducted to look at the carcinogenicity and chronic toxicity of copovidone (Kollidon VA 64) in Wistar rats and Beagle dogs. The results of these studies demonstrated the absence of any significant toxicological findings of high dietary levels of copodivone in rats and dogs, resulting in noobserved- adverse-effect levels of 2800 mg/kg body-weight/day in rats and 2500 mg/kg body-weight/day in dogs, the highest doses tested.
LD₅₀ (rat, oral): >0.63 g/kg

貯蔵

Copovidone is stable and should be stored in a well-closed container in a cool, dry place.

不和合性

Copovidone is compatible with most organic and inorganic pharmaceutical ingredients. When exposed to high water levels, copovidone may form molecular adducts with some materials; see Crospovidone and Povidone.

規制状況(Regulatory Status)

Copovidone is included in the FDA Inactive Ingredients Database (oral tablets, oral film-coated tablets, sustained action).