りん酸[(E)-1-メチル-3-(メチルアミノ)-3-オキソ-1-プロペニル]ジメチル

りん酸[(E)-1-メチル-3-(メチルアミノ)-3-オキソ-1-プロペニル]ジメチル 用途と合成の方法

• 外観

  白色〜わずかにうすい黄色, 結晶性粉末

• 溶解性

  水に混和。アルコール, エーテルに可溶。脂肪族炭化水素溶剤に不溶。水100%(20℃), アセトン70%, n-オクタノール25%,トルエン6%　(全て20℃)。水及びアセトンに溶ける。

• 用途

  農薬(殺虫剤)

• 農薬用途

  殺虫剤

• 使用上の注意

  アルゴン封入

• 化学的特性

  Monocrotophos is a colorless to reddishbrown solid with a mild ester odor.

• 使用

  Monocrotophos is an organophosphorous insecticide. Monocrotophos is used mainly against cotton pests but it is also used in the protection of citrus, rice, potatoes, vegetables and other crops.

• 定義

  ChEBI: An alkenyl phosphate that is the 4-(methylamino)-4-oxobut-2-en-2-yl ester of dimethyl phosphate.

• 一般的な説明

  Colorless crystals with a mild ester odor, commercial product is a reddish-brown solid. Used as a fast acting insecticide with both systemic and contact action against a wide range of pests on cotton, sugar cane, tobacco, potatoes, peanuts, tomatoes, and ornamentals. Very toxic.

• 空気と水の反応

  Water soluble. Rapidly hydrolyzed.

• 反応プロフィール

  Monocrotophos is incompatible with the following: Metals, low molecular weight alcohols & glycols [Note: Corrosive to black iron, drum steel, stainless steel 304 & brass. Should be stored at 70-80°F.] . Incompatible with alkaline compounds.

• 危険性

  Flammable, dangerous fire risk. Use may be restricted. Toxic via ingestion, inhala- tion, and skin absorption. Questionable carcinogen. Cholinesterase inhibitor.

• 健康ハザード

  Monocrotophos is an organophosphorus pesticide. It is a cholinesterase inhibitor and acts on the nervous system. Extremely toxic; probable oral lethal dose to humans 5-50 mg/kg or between 7 drops and 1 teaspoon for a 70 kg (150 lb.) person. Repeated inhalation or skin contact with Monocrotophos may, without symptoms, progressively increase susceptibility to poisoning.

• 火災危険

  Wear positive pressure breathing apparatus and full protective clothing. Container may explode in heat of fire. Toxic fumes evolved when heated to decomposition. Incompatible with alkaline compounds. Unstable in aqueous solution above pH 7.0; in low molecular weight alcohols and glycols. Stable in ketones and higher molecular weight alcohols and glycols. Stable when stored in glass or polyethylene containers. Relatively stable in sunlight. Keep away from temperatures above 80F; do not store below 70F. Corrosive to black iron, drum steel, stainless steel 304 and brass, but not to glass, aluminum, or stainless steel 316.

• 安全性プロファイル

  Poison by ingestion, inhalation, skin contact, intraperitoneal, subcutaneous, and intravenous routes. Mutation data reported. Use may be restricted. When heated to decomposition it emits very toxic NOx and POx.

• 職業ばく露

  The liquid form is a severely hazardous pesticide formulation. A potential danger to those involved in the manufacture, formulation, and application of this insecticide.

• 環境運命予測

  Plant. Decomposes in plants forming the N-hydroxy compound in small amounts (Hartley and Kidd, 1987).
  Chemical/Physical. Hua et al. (1995) studied the titanium dioxide-mediated photooxidation of monocrotophos using a recirculating photoreactor. The initial concentration and flow rate used were 50 nM and 30 mL/minute, respectively. The irradiation
  Emits toxic fumes of phosphorus and nitrogen oxides when heated to decomposition (Sax and Lewis, 1987; Lewis, 1990).

• 代謝経路

  Technical monocrotophos contains 75-80% of the Ε-isomer and 9% of the 2-isomer, the balance being various impurities. Most studies on the metabolic fate of this compound have used purified material containing >99% E-isomer. Monocrotophos is a systemic vinyl phosphate insecticide with a particularly high water solubility and low log K_ow. This hydrophilic property influences its metabolism and environmental fate in that it tends to remain in the water phase and does not bioaccumulate.
  The main routes of metabolic degradation are demethylation to des- O-methylmonocrotophos and hydrolysis to dimethylphosphate and N-methylacetoacetamide. Hydroxylation of the N-methyl group in animals and plants followed by N-demethylation are also important from a toxicological points of view, since these metabolic steps yield active acetylcholinesterase inhibitors.

• 輸送方法

  UN2783 Organophosphorus pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

• 不和合性

  Alkaline pesticides. Attacks black iron, drum steel; stainless steel; brass.

• 廃棄物の処理

  Small amounts may be hydrolyzed with water. Incineration in a unit with effluent gas scrubbing is recommended for larger amounts. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.