基本属性 生物活性体外研究 用途与合成方法 供应商 供应信息 相关产品
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THIAZOVIVIN

基本属性 生物活性体外研究 用途与合成方法 供应商 供应信息 相关产品
THIAZOVIVIN
THIAZOVIVIN 性质
  • 密度 1.379
  • 储存条件 Store at -20°C
  • 溶解度 DMSO: soluble20mg/mL, clear
  • 颜色, white to beige to brown
THIAZOVIVIN 用途与合成方法
  • 生物活性Thiazovivin是一种新型ROCK抑制剂,IC50为0.5 μM,在单细胞分离后,促进人胚胎干细胞(hESC)的存活。
  • 体外研究Although displaying little impact on cell proliferation, Thiazovivin treatment significantly enhances the survival of human embryonic stem cells (hESCs) after enzymatic dissociation more than 30-fold, while homogenously maintaining pluripotency with the characteristic colony morphology, expression of typical pluripotency markers such as alkaline phosphatase (ALP), and normal karyotype. Dissociated hESCs treated with Thiazovivin display dramatically increased adhesion to matrigel- or laminin-coated plates but not to gelatin-coated plates within a few hours. Thiazovivin treatment increases cell-ECM adhesion-mediated β1 integrin activity, which synergizes with growth factors to promote cell survival. In addition to activating integrin, Thiazovivin but not Tyrintegin (Ptn) protects hESCs from death in the absence of ECM in suspension through E-cadherin-mediated cell-cell interaction. Thiazovivin treatment potently inhibits endocytosis of E-cadherin, consequently stabilizing E-cadherin on the cell surface and leading to reestablishment of cell-cell interaction, which is essential for hESC survival in ECM-free conditions. Thiazovivin but not Tyrintegin (Ptn) at 2 μM inhibits Rho-associated kinase (ROCK) activity and protects hESCs at a similar level as the widely used selective ROCK inhibitor Y-27632 at 10 μM, suggesting that Rho-ROCK signaling regulates cell-ECM and cell-cell adhesion. Thiazovivin at 1 μM increases the reprogramming efficiency of CB mononuclear cells to induced pluripotent stem cells (iPSCs) by more than 10 times.
安全信息
  • 危险品标志 Xn
  • 危险类别码 22
THIAZOVIVIN供应商更多
  • 公司名称:上海东苍生物科技有限公司 黄金产品
  • 联系电话:+86-21-58447131
  • 产品介绍: 英文名称:Thiazovivin
    CAS:1226056-71-8
    纯度:>98% 包装信息:1g,5g,10g 备注:试剂级
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  • 公司名称:百灵威科技有限公司
  • 联系电话:400-666-7788 +86-10-82848833
  • 产品介绍: 英文名称:Thiazovivin
    CAS:1226056-71-8
    包装信息:100Mg,10Mg 备注:化学试剂、精细化学品、医药中间体、材料中间体
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  • 公司名称:武汉易泰科技有限公司上海分公司
  • 联系电话:86-21-50328103 * 801、802、803、804 Mobile:18930552037
  • 产品介绍: 英文名称:Thiazovivin;N-Benzyl-[2-(pyriMidin-4-yl)aMino]thiazole-4-carboxaMide
    CAS:1226056-71-8
    纯度:99% HPLC 包装信息:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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  • 公司名称:江苏弘和药物研发有限公司
  • 联系电话:86 510 85386188 ;86 510 85386988-8021
  • 产品介绍: 英文名称:N-benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide
    CAS:1226056-71-8
    纯度:>=95% 备注:CFP0829
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  • 公司名称:上海佰世凯化学科技有限公司
  • 联系电话:+86(0)21-20908456
  • 产品介绍: 英文名称:Thiazovivin
    CAS:1226056-71-8
    备注:C14252
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