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外観
白色～うすい褐色, 結晶性粉末～粉末
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溶解性
水 5.1mg/ml at28℃ 。メタノール6.55, エタノール2.0, イソプロパノール0.16, 酢酸エチル1.3, クロロホルム, 0.01, 石油エーテル0.025。うすい塩酸に溶け、水、エタノール及びアセトンにほとんど溶けない。
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用途
抗生物質。
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用途
ペプチド系抗生物質です。細
菌の細胞壁ペプチドグリカン生合成系を阻害
します。グラム陽性菌に抗菌作用を示します。
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説明
Bacitracin zinc is a zinc complex of bacitracin, a polypeptide produced by the growth of an organism of the licheniformis group of Bacillus subtilis. The main components are Bacitracin A, B1 and B2.Bacitracin zinc has antibiotic activity against a variety of Gram-positive bacteria including staphylococci. The zinc complex adds stability to the component, making bacitracin zinc more stable compared to bacitracin.
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化学的特性
a white or pale brownish yellow powder; odourless or with a faint characteristic odour. Soluble in 900 parts of water and in 500 parts of ethanol (~750 g/l) TS; very slightly soluble in ether R. small amounts of bacitracin zinc are dissolved in petroleum jelly to create antibiotic ointments.
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使用
Bacitracin zinc is a dephosphorylation of the C55-isoprenyl pyrophosphate interference for inhibition of cleavage of Tyr from Met-enkephalin with IC50 of 10 μM.
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適応症
Bacitracin zinc is composed of a group of polypeptides with antibiotic activity against a variety of Gram-positive bacteria including staphylococci. It is used in the treatment of local infections, mainly infections of the skin, ear and eye.
