基本属性 生物活性靶点体外研究体内研究 用途与合成方法 氢溴酸卤夫酮 价格(试剂级) 供应商 供应信息 相关产品
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氢溴酸卤夫酮

氢溴酸卤夫酮

中文名称:氢溴酸卤夫酮
英文名称:Halofuginone hydrobromide
CAS号:64924-67-0
分子式:C16H17BrClN3O3.HBr
分子量:495.59
EINECS号:
Mol文件:64924-67-0.mol
氢溴酸卤夫酮 结构式

氢溴酸卤夫酮 性质

熔点 247° (dec)
储存条件 Store at -20°C
溶解度 在DMSO中水中的溶解度为至100mM。

氢溴酸卤夫酮 用途与合成方法

Halofuginone hydrobromide (RU-19110 hydrobromide) 是 Febrifugine 的一种低毒性衍生物,可从 Dichroa febrifuga 中分离出来。Halofuginone 是一种 ATP 竞争性的脯氨酰-tRNA 合成酶 (prolyl-tRNA synthetase) 抑制剂,Ki 为 18.3 nM。Halofuginone 是 I 型胶原 (type-I collagen) 合成的特异性抑制剂,并通过抑制 TGF-β 活性可减轻骨关节炎。

Ki: 18.3±0.5 nM (prolyl-tRNA synthetase)

Halofuginone competitively inhibits prolyl-tRNA synthetase by occupying both the prolineand tRNA-binding pockets of prolyl-tRNA synthetase.
The IC 50 s of Halofuginone (1, 10, 100, 1000, 10000 nM; 48 hours) are 114.6 and 58.9 nM in KYSE70 and A549 cells, respectively.
The IC 50 s of Halofuginone (1, 10, 100, 1000 nM; 24 hours) for NRF2 protein are 22.3 and 37.2 nM in KYSE70 and A549 cells, respectively. The IC 50 of Halofuginone for global protein synthesis is 22.6 and 45.7 nM in KYSE70 and A549 cells, respectively.

Cell Viability Assay

Cell Line: KYSE70 cells from human oesophageal cancer harbouring a mutation in the NRF2 gene and A549 cells harbouring the KEAP1 gene mutation
Concentration: 1, 10, 100, 1000, 10000 nM
Incubation Time: 48 hours
Result: The IC 50 s were 114.6 and 58.9 nM in KYSE70 and A549 cells, respectively.

Western Blot Analysis

Cell Line: KYSE70 cells from human oesophageal cancer harbouring a mutation in the NRF2 gene and A549 cells harbouring the KEAP1 gene mutation
Concentration: 1, 10, 100, 1000 nM
Incubation Time: 24 hours
Result: The IC 50 s for NRF2 protein were 22.3 and 37.2 nM in KYSE70 and A549 cells, respectively.

Halofuginone (0.2, 0.5, 1 or 2.5 mg/kg; injected intraperitoneally every other day for 1 month) attenuates progression of OA in anterior cruciate ligament transection (ACLT) mice. Lower concentration (0.2 or 0.5 mg/kg) has minimal effects on subchondral bone and higher concentration (2.5 mg/kg) induces proteoglycan loss in articular cartilage.
Halofuginone (0.25 mg/kg; intraperitoneally injected; every day; 16 days) decreases NRF2 protein levels in tumors. While the tumor volumes do not change substantially between treatments with the vehicle, Halofuginone (0.25 mg/kg, intraperitoneally injected, every day) or cisplatin alone. Combined treatment with Halofuginone and Cisplatin significantly suppresses the tumor volume compared to treatment with Halofuginone or cisplatin alone.

Animal Model: 3-month-old male C57BL/6J (WT) mice
Dosage: 0.2, 0.5, 1 or 2.5 mg/kg
Administration: Injected intraperitoneally every other day for 1 month
Result: Attenuated progression of OA in ACLT mice.
Animal Model: Male nude mice (BALB/C nu/nu mice) (6-8-week)
Dosage: 0.25 mg/kg
Administration: Intraperitoneally injected; every day; 16 days
Result: The combined treatment with Cisplatin significantly suppressed the tumor volume. NRF2 protein levels in tumors were indeed decreased.

安全信息

危险品标志Xn
危险类别码22
危险品运输编号UN2811 - class 6.1 - PG 1 - EHS - Toxic solids, organic, n.o.s., HI: all
WGK Germany3
RTECS号VA2397066

氢溴酸卤夫酮 价格(试剂级)

更新日期 产品编号 产品名称 CAS号 包装 价格
2024-01-25 HY-N1584A 氢溴酸卤夫酮 64924-67-0 5mg 1200
2024-01-25 HY-N1584A 氢溴酸卤夫酮 64924-67-0 10mM * 1mLin DMSO 1320

氢溴酸卤夫酮供应商 更多

武汉多普乐生物医药有限公司
黄金产品 现货
联系电话:+86-02787215551 +86-19945035818
产品介绍:
中文名称:常山酮氢溴酸盐
英文名称:Halofuginone Hydrobromide
CAS:64924-67-0
纯度:98% hplc lcms
包装信息:5MG;10MG;50MG;100MG,1G,5G, 5KG;1KG
备注:大量优势现货产品,可以随时联系,微信QQ24小时在线19945035818,质量好,包装好。化学试剂、精细化学品、医药中间体、材料中间体
库存量:10g
现货日期:2024/3/29 9:13:35
苏州科为化学有限公司
黄金产品
联系电话:512-62706911 13401923197
产品介绍:
中文名称:氢溴酸常山酮
英文名称:Halofuginone Hydrobromide
CAS:64924-67-0
纯度:98%
包装信息:1kg;5kg
备注:可大量供应,有生产许可
湖北科乐精细化工有限公司
大货 现货
联系电话:027-59101668 19945030958
产品介绍:
中文名称:常山酮氢溴酸盐
英文名称:Halofuginone Hydrobromide
CAS:64924-67-0
纯度:98% HPLC
包装信息:5KG;1KG;100g;1g
库存量:1g
现货日期:2024/3/29 9:23:56
武汉沃格达生物科技有限公司
现货
联系电话: 15071299552
产品介绍:
中文名称:氢溴酸卤夫酮
英文名称:Halofuginone hydrobromide
CAS:64924-67-0
纯度:98%
包装信息:mg;g;kg
备注:自有实验室,可接定制单,质量控制严格,发货必检!专业售前售后客服,确保您购物无忧!
库存量:83mg
现货日期:2024/3/29 9:14:01
北京百灵威科技有限公司
联系电话:010-82848833 400-666-7788
产品介绍:
英文名称:Halofuginone HydrobroMide
CAS:64924-67-0
包装信息:10Mg,1Mg
备注:化学试剂、精细化学品、医药中间体、材料中间体

氢溴酸卤夫酮生产厂家及价格列表

氢溴酸常山酮
湖北阡陌生物科技有限公司 2024-03-29
氢溴酸常山酮
江西瑞威尔生物科技有限公司 2024-03-29

"氢溴酸卤夫酮"相关产品信息