(9E)-9-十六烯酸
(9E)-9-十六烯酸 性质
| 熔点 | 33-34℃ |
|---|---|
| 沸点 | 374.4°C (estimate) |
| 密度 | 0.8855 (rough estimate) |
| 折射率 | 1.4501 (589.3 nm 40℃) |
| 储存条件 | Amber Vial, Refrigerator |
| 溶解度 | 可溶于DMSO（少量）、甲醇（少量） |
| 酸度系数(pKa) | 4.78±0.10(Predicted) |
| 形态 | 液体 |
| 颜色 | 白色至类白色 |
| LogP | 6.635 (est) |
| EPA化学物质信息 | 9-Hexadecenoic acid, (9E)- (10030-73-6) |
(9E)-9-十六烯酸 用途与合成方法
|
AMPK
|
PPARα
|
Glucokinase
|
The monounsaturated fatty acid palmitoleate (palmitoleic acid) is one of the most abundant fatty acids in serum and tissues, particularly adipose tissue and liver. Its endogenous production by stearoyl-CoA desaturase 1 gives rise to its cis isoform, cis-palmitoleate. Palmitoleic acid has been correlated with multiple cardiometabolic risk factors, including high blood pressure, total cholesterol, TGs, apoA-I, apoB, and endothelial dysfunction.
Palmitoleic acid promotes a faster uptake of glucose in the body, associated with higher insulin concentration. Palmitoleic acid increases the phosphorylation of AMPK, up-regulates glucokinase and down-regulates SREBP-1. Regarding AMPK downstream, palmitoleic acid increases the production of FGF-21 and stimulates the expression of PPARα. Palmitoleic acid reduces body weight increase, ameliorates the development of hyperglycemia and hypertriglyceridemia, and improves insulin sensitivity. Furthermore, palmitoleic acid down-regulates mRNA expressions of proinflammatory adipocytokine genes (TNFα and resistin) in white adipose tissue and lipogenic genes (SREBP-1, FAS, and SCD-1) in liver.
(9E)-9-十六烯酸 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-04-30 | HY-N2341 | (9E)-9-十六烯酸 | 10030-73-6 | 10mg(393mM * 100μL in Ethanol) | 500 |
| 2024-04-30 | HY-N2341 | 25 mg (393 mM * 250 μL in Ethanol) | 1000 |
