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外観
白色～うすい赤褐色, 結晶～結晶性粉末
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溶解性
水に不溶, エタノールに易溶, アセトンに可溶。エタノールに溶けやすく、アセトンに溶け、水にほとんど溶けない。
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用途
農薬(除草剤) (NITE CHRIP)
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農薬用途
除草剤
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説明
2,4-D free acids, esters, amines, and salts are formulated in
water suspensions or solutions, or in various organic solvents,
for application as systemic herbicides that are used postemergence
for selective control of broadleaf weeds.
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化学的特性
2,4-Dichlorophenoxyacetic acid is a white to yellow crystalline powder with a slight phenolic odor. It is used as a herbicide for the selective control of broad-leaved weeds in agriculture, and for the control of woody plants along roadsides, railways, and utilities rights of way. It is one of the most widely used herbicides in the world and is commonly used on crops such as wheat and corn, and on pasture and rangelands. It is also used to control broad-leaved aquatic weeds.
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物理的性質
Odorless, white to pale yellow, powder or prismatic crystals. Impure formulations containing 2,4-
D as the main component may have a phenolic odor.
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使用
2,4-Dichlorophenoxyacetic acid is often formulated as various
forms of inorganic salts or esters. 2,4-D was first registered
as a herbicide in 1948, and its annual production was
estimated at 52–67 million lb in 1990. The primary use
of 2,4-D is for control of broadleaf weeds, and as such, it is
used for a large spectrum of applications in agriculture,
forestry, and lawn care. 2,4-D also is used along right-ofways,
on rangelands, parks, and in aquatic environments.
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定義
ChEBI: A chlorophenoxyacetic acid that is phenoxyacetic acid in which the ring hydrogens at postions 2 and 4 are substituted by chlorines.
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製造方法
Two processes are currently used for the production of 2,4-Dichlorophenoxyacetic acid. In the first process, phenol is condensed with chloroacetic acid forming phenoxyacetic acid, which is subsequently chlorinated. In the second process, phenol is chlorinated, generating 2,4-dichlorophenol, which is subsequently condensed with chloroacetic acid. The butyl ester derivative of 2,4-D is produced by the esterification of the acid with butanol in the presence of a ferric chloride catalyst and chlorine (Liu et al., 2013).
Preparation of 2,4-Dichlorophenoxyacetic acid
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一般的な説明
Odorless white to tan solid. Sinks in water.
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空気と水の反応
Decomposes rapidly in water.
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反応プロフィール
2,4-Dichlorophenoxyacetic acid is incompatible with strong oxidizers. 2,4-Dichlorophenoxyacetic acid is corrosive to metals.
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火災危険
Special Hazards of Combustion Products: Toxic and irritating hydrogen chloride or phosgene gases may form.
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农业用途
Herbicide, Plant growth regulator: 2,4-Dichlorophenoxyacetic acid was introduced as a plant growth-regulator in 1942. 2, 4-D is the most widely used herbicide in the United States and its used in more than 100 countries. It is registered in the United States as a herbicide for control of broadleaf plants and as a plant growth-regulator. There are many forms or derivatives of 2,4-D including esters, amines, and salts. It is used in cultivated agriculture, in pasture and rangeland applications, forest management, home, garden, and to control aquatic vegetation. It may be found in emulsion form, in aqueous solutions (salts), and as a dry compound. The product Agent Orange, made by Monsanto Chemical and used extensively throughout Vietnam, was about 50% 2,4-D. However, the controversies associated with the use of Agent Orange involved a contaminant (dioxin) in the 2,4,5-T component of the defoliant. In 1964 Agent Orange replaced Agent Purple a mixture of the n-butyl esters of 2,4-D and 2,4,5-T plus the isobutyl ester of 2,4,5-T.
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製品名
Hedonal; 2,4-D; Estone; Agrotect; Fernesta; Fernimine; Netagrone; Tributon; Vergemaster; Amoxone; Dicopur; Dormone; Ipaner; Moxone; Phenox; Pielik; Rhodia; Weedone; B-Selektonon.
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職業ばく露
2,4-Dichlorophenoxyacetic acid,
was introduced as a plant growth-regulator in 1942. It
is registered in the United States as a herbicide for control
of broadleaf plants and as a plant growth-regulator. Thus,
workers engaged in manufacture, formulation or application
are affected, as may be citizens in areas of application. The
Vietnam war era defoliant, Agent Orange, was a mixture of
2,4-D and 2,4,5-T.
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発がん性
Collectively, the epidemiological
and toxicological data show that 2,4-D is not likely to be
carcinogenic in humans unless it is acting through an
unknown mechanism that is not evident in animals. According
to the calculated RfD and data from exposure studies, the
general public should not experience toxic effects from
exposure to 2,4-D. Because workers involved in the manufacture
or application of 2,4-D may be exposed to levels
above the RfD, appropriate protective equipment should be
used.
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環境運命予測
2,4-Dichlorophenoxyacetic acid (2,4-d) is rapidly degraded by microbes in soil and water, with a half-life of 3-22 days in different soils. 2,4-d is weakly sorbed by soil with sorption generally increasing with increasing soil organic carbon content. Leaching to groundwater is most likely in coarse-grained sandy soils with low organic content or with very basic soils. In general, little runoff occurs with 2,4-d or its amine salts.
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代謝
Chemical. 2,4-D and its salts are very stable, but
esters are sensitive to hydrolysis under acidic and basic conditions. In the field, 2,4-D losses due to
photodegradation are minor. 2,4-D is a strong acid and
forms water-soluble salts with amines and alkali metals.
A sequestering agent is included in 2,4-D formulations to
prevent precipitation of Ca2+ andMg2+ salts in hard water.
Plant. 2,4-D detoxification occurs relatively slowly in
plants. There are many possible routes of detoxification,
and these are usually grouped into those reactions that are
consistent with phase I metabolism and those that are consistent
with phase II metabolism. Phase I reactions that
have been observed to occur with 2,4-D include dechlorination,
decarboxylation, hydroxylation, and dealkylation.
Phase II reactions that have been observed to occur
with 2,4-D include conjugation of the side chain to
amino acids, particularly glutamate and aspartate, and glucose conjugation following hydroxylation of the phenoxy
ring. Selectivity differences among broadleaf species
may be accounted for by differences in the rates of 2,4-D
detoxification.
Soil. Microbial degradation in the soil involves cleavage
of the acid side chain, decarboxylation, hydroxylation, and
ring opening.
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輸送方法
UN3345 Phenoxyacetic acid derivative pesticide,
solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous
materials. A DOT regulated marine pollutant.
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純化方法
Crystallise 2,4-D from MeOH. It is a plant growth substance, a herbicide and is TOXIC. [Beilstein 6 IV 908.]
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不和合性
A weak acid, incompatible with bases.
Decomposes in sunlight or heat, forming hydrogen chloride
and phosgene. Contact with strong oxidizers may cause fire
and explosions.
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廃棄物の処理
Incineration of phenoxys is effective in 1 second @ 982 C, using a straight combustion process or @ 482℃ using catalytic combustion. Over 99% decomposition was reported when small amounts of 2,4-D were burned in a polyethylene bag. See "References" for additional detail. In accordance with 40CFR165, follow (31); recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by follow- ing (100) Package (2) label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.
