シブトラミン塩酸塩一水和物

効能

食欲抑制薬, 抗うつ薬, セロトニン・ノルアドレナリン再取り込み阻害薬

説明

Sibutramine was introduced as Meridia in the US for the control of obesity, in conjunction with a reduced-calorie diet. Sibutramine can be prepared in four steps from 4-chlorobenzyl cyanide. Sibutramine acts as a serotonin and noradrenaline reuptake inhibitor ; in animal studies, it reduces energy intake by creating a satieted feeling and increases energy expenditure by enhancing thermogenesis. In a clinical study in obese patients treated with 10 or 15 mg of Sibutramine once-daily, meaningful weight loss was sustained for 12 months ; an additional study demonstrated a lack of abuse potential. An appreciable part of Sibutramine's effect would also be due to its 2N-mono and didesmethylmetabolites, which are very potent monoamine reuptake inhibitors themselves.

化学的特性

White Solid

使用

A serotonin and noradrenaline reuptake inhibitor (SNR). Decreases calorie intake and increases energy expenditure