1-(4-ビフェニリルオキシ)-3,3-ジメチル-1-(1H-1,2,4-トリアゾール-1-イル)-2-ブタノール CAS#: 55179-31-2

ChemicalBook 製品カタログ化学農薬防腐剤アゾール系殺菌剤 1-(4-ビフェニリルオキシ)-3,3-ジメチル-1-(1H-1,2,4-トリアゾール-1-イル)-2-ブタノール

1-(4-ビフェニリルオキシ)-3,3-ジメチル-1-(1H-1,2,4-トリアゾール-1-イル)-2-ブタノール

化学名:1-(4-ビフェニリルオキシ)-3,3-ジメチル-1-(1H-1,2,4-トリアゾール-1-イル)-2-ブタノール

英語化学名:Bitertanol

CAS番号:55179-31-2

分子式:C20H23N3O2

分子量:337.42

EINECS:259-513-5

MOL File55179-31-2.mol

1-(4-ビフェニリルオキシ)-3,3-ジメチル-1-(1H-1,2,4-トリアゾール-1-イル)-2-ブタノール性質

融点	49-50°C
沸点	350°C
比重(密度)	1.1676 (rough estimate)
蒸気圧	A 2.2 x l0^-10 (20 °C) B 2.5 x l0^-9 (20 °C)
屈折率	1.6200 (estimate)
闪点	100 °C
溶解性	Chloroform: slightl soluble,DMSO: Slightly Soluble,Methanol: Slightly Soluble
水溶解度	A：2.7mg・l-1 (20℃); B: 1.1mg・l-1 (20℃)
酸解離定数(Pka)	13.40±0.20(Predicted)
Merck	13,1301
BRN	620948
NISTの化学物質情報	1H-1,2,4-triazole-1-ethanol, «beta»-([1,1'-biphenyl]-4-yloxy)-«alpha»-(1,1-dimethylethyl)-(55179-31-2)
EPAの化学物質情報	Bitertanol (55179-31-2)

セキュリティ情報

主な危険性	T
Rフレーズ	22-23
Sフレーズ	45
RIDADR	UN 2811
WGK Germany	2
RTECS 番号	XZ4803050
毒性	LD50 in rats, male and female mice (mg/kg): >5000, 4488, 4202 orally (Brandes)

MSDS Information

1-(4-ビフェニリルオキシ)-3,3-ジメチル-1-(1H-1,2,4-トリアゾール-1-イル)-2-ブタノール用途と合成の方法

外観

白色, 結晶性粉末〜粉末
溶解性

混合物 : 水5mg/l(20℃)。異性体A:水2.9mg/l(20℃)。n-ヘキサン0～1,トルエン10～20, イソプロパノール20～50, ジクロロメタン200～500 (全てg/l 20℃)。異性体B:水1.6mg/l(20℃)。n-ヘキサン0～1,トルエン1～2, イソプロパノール20～50, ジクロロメタン50～100 (全てg/l 20℃)。アセトンに溶け、水にほとんど溶けない。
説明

Bitertanol is a broad-spectrum triazole fungicide that is active against a variety of fungi, including V. inaequalis and V. pirina, which are responsible for apple and pear scab, respectively, as well as S. mors-uvae and P. ribis, which are responsible for American gooseberry mildew and leaf spot in black currants, respectively. It is active against isolates of V. inaequalis (MICs = 0.6 and 1 μg/ml) but repeated use leads to resistance and cross-resistance (MICs = 9.8-13 μg/ml for bitertanol-resistant isolates). Bitertanol inhibits the cytochrome P450 (CYP450) isoform CYP3A4 (IC₅₀ = 2.74 μM) and inhibits androgenic activity induced by the androgen receptor agonist DHT in a yeast two-hybrid assay (IC₅₀ = 79.85 μM). In rats, bitertanol (10-300 mg/kg, i.p.) increases operant responding on one- and five-minute fixed interval schedules with no effect on motor activity.
化学的特性

White Solid
使用

Bitertanol is a foliar-applied triazole fungicide used to protect tropical and subtropical crops in agriculture, in particular bananas. Bitertanol has effects on behavior that are similar to those of psychomotor stimulants.
农业用途

Fungicide: A fungicide used to control a variety of diseases. Used as control for prunes when drying. Not currently registered in the U.S. or EU countries (pending). Used in many European, South American, Far Eastern and African countries, a well as in Australia for use on beans (all types) and various ornamentals. More than 20 global suppliers.
製品名

BAYCOR®; BAY KWG 0599®; BAYMATSPRAY ®; BILOXAZOL®; KWG 0599®; SIBUTOL®, (with Fuberidazole)
代謝経路

Bitertanol is a mixture of two diastereoisomeric pairs and this complicates its metabolism, each biotransfonnation affording a mixture of isomers. Metabolism has been studied under environmental conditions and in plants and mammals. Degradation in soil and sediments is slow and only small quantities of products (other than CO₂ and bound residues) are produced. Most information is available for mammals in which metabolism occurs mainly by oxidative routes followed by conjugation. The information presented below is derived from the UK MAFF Pesticide Safety Directorate (PSD, 1994).

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1-(4-ビフェニリルオキシ)-3,3-ジメチル-1-(1H-1,2,4-トリアゾール-1-イル)-2-ブタノール

MSDS Information

1-(4-ビフェニリルオキシ)-3,3-ジメチル-1-(1H-1,2,4-トリアゾール-1-イル)-2-ブタノール 用途と合成の方法

1-(4-ビフェニリルオキシ)-3,3-ジメチル-1-(1H-1,2,4-トリアゾール-1-イル)-2-ブタノールサプライヤー

1-(4-ビフェニリルオキシ)-3,3-ジメチル-1-(1H-1,2,4-トリアゾール-1-イル)-2-ブタノール用途と合成の方法