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定義
本品は、エチレンジアミン四酢酸(EDTA(*))の二ナトリウム塩であり、次の化学式で表されるジアミン誘導体である。
参照表示名称：ＥＤＴＡ
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化粧品の成分用途
キレート剤
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効能
金属キレート剤
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化学的特性
Disodium edetate occurs as a white crystalline, odorless powder
with a slightly acidic taste.
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使用
Ethylenediaminetetraacetic acid disodium salt is widely used in textile industry. Usually applied to dissolve limescale. It is applied in textile industry, pulp and paper industry and also in chelation therapy. In cosmetics, it acts as a sequestering agent. It acts as a corrosion inhibitor to carbon steel in the industries. It also acts as a food additive.
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主な応用
Ethylenediaminetetraacetic acid disodium salt dihydrate has been in seed germination trials of plant species and in protein extraction from Moss, Physcomitrella paten. It has also been used in lysis and vacuole buffer for the isolation of vacuoles from Petunia petals.
Chelator of divalent cations. Inhibits enzymes, such as metalloproteases, that require divalent cations for activity.
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調製方法
Disodium edetate may be prepared by the reaction of edetic acid
and sodium hydroxide.
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定義
ChEBI: An organic sodium salt that is the anhydrous form of the disodium salt of ethylenediaminetetraacetic acid (EDTA).
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一般的な説明
Ethylenediamine tetraacetate (EDTA) is a calcium ion chelator, that has a low molecular mass of 292.24 Da.
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応用例（製薬）
Disodium edetate is used as a chelating agent in a wide range of
pharmaceutical preparations, including mouthwashes, ophthalmic
preparations, and topical preparations, typically at concentrations
between 0.005 and 0.1% w/v.
Disodium edetate forms stable water-soluble complexes (chelates)
with alkaline earth and heavy-metal ions. The chelated form
has few of the properties of the free ion, and for this reason
chelating agents are often described as ‘removing’ ions from
solution, a process known as sequestering. The stability of the
metal–edetate complex is dependent on the metal ion involved and
the pH.
Disodium edetate is also used as a water softener as it will chelate
calcium and magnesium ions present in hard water. It is also used
therapeutically as an anticoagulant as it will chelate calcium and
prevent the coagulation of blood in vitro. Concentrations of 0.1%
w/v are used in small volumes for hematological testing and 0.3%
w/v in transfusions.
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安全性プロファイル
Poison by
intraperitoneal and intravenous routes.
Moderately toxic by ingestion. Experimental
teratogenic and reproductive effects.
Mutation data reported. The calcium
disodium salt of EDTA is used as a
chelating agent in treating lead poisoning.
When heated to decomposition it emits
toxic fumes of NOx and NasO.
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貯蔵
Edetate salts are more stable than edetic acid (see also Edetic acid).
However, disodium edetate dihydrate loses water of crystallization
when heated to 120°C. Aqueous solutions of disodium edetate may
be sterilized by autoclaving, and should be stored in an alkali-free
container.
Disodium edetate is hygroscopic and is unstable when exposed
to moisture. It should be stored in a well-closed container in a cool,
dry place.
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不和合性
Disodium edetate behaves as a weak acid, displacing carbon dioxide
from carbonates and reacting with metals to form hydrogen. It is
incompatible with strong oxidizing agents, strong bases, metal ions,
and metal alloys.
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規制状況(Regulatory Status)
GRAS listed. Included in the FDA Inactive Ingredients Database
(inhalations; injections; ophthalmic preparations; oral capsules,
solutions, suspensions, syrups, and tablets; rectal topical, and
vaginal preparations). Included in nonparenteral and parenteral
medicines licensed in the UK. Included in the Canadian List of
Acceptable Non-medicinal Ingredients.
