イソプロチオラン

外観

白色～わずかにうすい黄色, 結晶～結晶性粉末

溶解性

エタノール及びアセトンに溶け、水にほとんど溶けない。

用途

農薬(ジチオラン系の殺菌剤:稲いもち病防除剤)

農薬用途

動物薬、殺菌剤、成長調整剤、強肝剤

使用

Isoprothiolane is a dithiolane pesticide. Isoprothiolane is commonly used in agriculture as a fungicide to control planthoppers and blast disease in rice plants.

危険性

Moderately toxic by ingestion.

代謝経路

Isoprothiolane is easily oxidized by rat liver 9000 g supernatant to produce its racemic sulfoxide in this process, NADPH is an effective cofactor but NADH is not. The liver microsomes, however, preferentially form its (?+)-isomer in an enantiomeric excess of 38-43%. The sulfoxidation of isoprothiolane by rice plants proceeds too slowly to determine the metabolites. Both isoprothiolane (+?)- and (-)- sulfoxides undergo rapid racemization by rat cytosol (105 000 g supernatant) or rice plants, accompanied with reduction to isoprothiolane.