富马酸单甲酯
富马酸单甲酯 性质
| 熔点 | 144-145 °C (lit.) |
|---|---|
| 沸点 | 250.0±23.0 °C(Predicted) |
| 密度 | 1.37 g/cm3 |
| 储存条件 | 2-8°C |
| 溶解度 | 可溶于氯仿（少许）、DMSO（少许）、甲醇（少许） |
| 酸度系数(pKa) | 3.40±0.10(Predicted) |
| 形态 | 固体 |
| 颜色 | 米白色 |
| 最大波长(λmax) | 209nm(MeOH)(lit.) |
| CAS 数据库 | 2756-87-8(CAS DataBase Reference) |
富马酸单甲酯 用途与合成方法
| Target | Value |
|
GPR109A
() |
Monomethyl fumarate completely inhibits forskolin induced cAMP synthesis with an IC
50
of 70 nM. Monomethyl fumarate induces a dose-dependent Ca
2+
signal in GPR109A transfected cells with an EC
50
of 9.4 μM.
Monomethyl fumarate (25 μM; 24 hours) attenuates 7β-OHC-induced cytotoxicity: cell growth inhibition; decreased cell viability; mitochondrial dysfunction; and cell death induction.
A single dose of Monomethyl fumarate (50-100 mg/kg; IP) before light exposure prevents these morphologic changes (bright light exposure induced photoreceptor death) in a dose-dependent manner.
Monomethyl fumarate (100 mg/kg) reduces retinal inflammation and oxidative stress. Monomethyl fumarate significantly suppresses light-induced retinopathy (LIR) upregulated genes in the NFkB pathway including: Nlrp3, Casp1, Il-1β, and Tnf-α.
| Animal Model: | Albino BALB/c mice (male, 6 weeks old) |
| Dosage: | 50, 65, 75, 100 mg/kg |
| Administration: | IP |
| Result: | Prevented these morphologic changes (bright light exposure induced photoreceptor death) in a dose-dependent manner. |
富马酸单甲酯 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-01-25 | HY-103252 | 富马酸单甲酯 | 2756-87-8 | 500mg | 500 |
| 2024-01-25 | HY-103252 | 富马酸单甲酯 | 2756-87-8 | 10mM * 1mLin DMSO | 550 |
