ブロモ酢酸

外観

白色〜褐色, 結晶又は塊

溶解性

水、エタノール及びアセトンに溶けやすい。

解説

モノブロモ酢酸：C2H3BrO2(138.95)．BrCH2COOH．酢酸と無水酢酸の混合物をピリジンに溶かし，臭素を作用させると得られる．無色のりょう面結晶．融点49～50 ℃，沸点208 ℃，118 ℃(2 kPa)．d²⁰₄ 1.934．pKa 2.903(25 ℃)．いずれも水，エタノール，エーテルに易溶，石油エーテルに難溶．種々の合成原料に用いられるが，腐食性があり，皮膚をおかすので取り扱いに注意を要する．

用途

有機合成(医薬、殺菌剤、農薬)原料。

用途

医薬品原料、殺菌剤原料

用途

ブロモ酢酸とそのエステルは、出発原料または反応中間体として利用

使用上の注意

強刺激性、催涙性。皮膚等に触れないように注意する。潮解性あり

化学的特性

WHITE TO LIGHT YELLOW CRYSTALLINE MASS

使用

Bromoacetic acid is used in organic synthesis and as an alkylating agent. It is also used as a biochemical for proteomics research. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, dyes and agrochemicals.

一般的な説明

Aqueous solution.

空気と水の反応

Water soluble.

危険性

Strong irritant to skin and tissue.

健康ハザード

TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Contact with molten substance may cause severe burns to skin and eyes. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

火災危険

Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.

安全性プロファイル

Poison by ingestion, intraperitoneal, and intravenous routes. Irritating and corrosive to skin and mucous membranes. Mutation data reported. When heated to decomposition it emits toxic fumes of Br-. See also BROMIDES.

純化方法

Crystallise bromoacetic acid from pet ether (b 40-60o). A diethyl ether solution of it is passed through an alumina column, and the ether is evaporated at room temperature under vacuum. It is best obtained by distillation from a Claisen (flask immersed in an oil bath) fitted with an insulated Vigreux column (p 11) and the fraction b 108-110o/30mm is collected. It is light and moisture sensitive. [Natelson & Gottfried Org Synth Coll Vol III 381 1955, Beilstein 2 IV 526.] LACHRYMATORY and is a skin IRRITANT.