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外観
暗黄色～黄褐色, 結晶性粉末～粉末
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溶解性
水に難溶, エタノール, エーテル, アセトンに可溶。エタノールに溶け、水にほとんど溶けない。
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用途
染料?顔料中間体 (化学工業日報社)
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説明
2-Methyl-5-nitroaniline, also known as 5-nitro-o-toluidine, is an intermediate compound in the synthesis of a wide range of azo dyes and is an in vivo metabolic product of 2,4-dinitrotoluene.
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使用
2-Methyl-5-nitroaniline may be employed as analytical standard for the surfactant mediated transformations (?254nm) of 2,4-dinitrotoluene.
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定義
ChEBI: A C-nitro compound in which the nitro compound is meta to the amino group and para to the methyl group of o-toluidine.
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製造方法
2-Methyl-5-nitrobenzenamine?in concentrated sulfuric acid nitration.
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空気と水の反応
Insoluble in water. 2-Methyl-5-nitroaniline is sensitive to moisture, light, or prolonged exposure to air.
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反応プロフィール
2-Methyl-5-nitroaniline is incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides and chloroformates.
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火災危険
Flash point data for 2-Methyl-5-nitroaniline are not available; however, 2-Methyl-5-nitroaniline is probably combustible.
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安全性プロファイル
Confirmed carcinogen
with experimental carcinogenic data.
Moderately toxic by ingestion. Mutation data
reported. Decomposes exothermically when
heated to 150℃. When heated to
decomposition it emits toxic fumes of NOx.
See also NITRO COMPOUNDS OF
AROMATIC HYDROCARBONS.
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発がん性
There
are no data available for evaluating carcinogenic risk to
humans. When 5-nitro-o-toluidine was administered in a
dietary feeding study to F344 rats (50 or 100 ppm) and
B6C3F1 mice (1200 or 2300 ppm) of both sexes, hepatocellular
carcinomas were produced in mice but not in rats.
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輸送方法
UN2660 Nitrotoluidines (mono), Hazard Class:
6.1; Labels: 6.1-Poisonous materials.
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純化方法
Acetylate the aniline, and the acetyl derivative is crystallised to constant melting point; then hydrolyse it with 70% H2SO4 and the free base is regenerated by treatment with NH3 [Bevan et al. J Chem Soc 4284 1956]. [Beilstein 12 H 844. 12 IV 1807.]
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不和合性
Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.); contact may cause fires or explosions.
Keep away from alkaline materials, strong bases,
strong acids, oxoacids, epoxides, acid chlorides; acid anhydrides;
chloroformates.
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廃棄物の処理
Consult with environmental
regulatory agencies for guidance on acceptable disposal
practices. Generators of waste containing this contaminant
(≥100 kg/mo) must conform with EPA regulations governing
storage, transportation, treatment, and waste disposal.
