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用途
黄体形成ホルモン放出ホルモ
ンとして作用します。
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効能
抗悪性腫瘍薬, 性腺刺激ホルモン放出ホルモン受容体作動薬
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商品名
リュープリン (武田薬品工業); リュープリン (武田薬品工業); リュープリン (武田薬品工業)
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説明
Leuprolide acetate is a potent analog of LH-RH useful in achieving a medical
castration in the treatment of advanced prostate cancer. It has also been
investigated for the treatment of advanced breast cancer.
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化学的特性
Fluffy Solid
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使用
Synthetic nonapeptide agonist analog of LH-RH. Antineoplastic (hormonal).
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定義
ChEBI: An acetate salt obtained by combining the nonapeptide leuprolide with acetic acid. A long lasting GnRH analog, LH-Rh agonist. It is a synthetic nonapeptide analogue of gonadotropin-releasing hormone, and is used as a subcutaneous hydrogel implant for the t
eatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty.
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薬理学
Leuprolide, 5-oxo-L-prolyl-L-histadyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucil-L-leucil-L-arginyl-N-ethyl-L-prolinamide (30.5.9), is made synthetically.
pyroGlu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt
The nonapeptide leuprolide is a synthetic analog of the decapeptide, gonadotropin releasing hormone, and it exceeds the activity of the natural hormone and significantly elevates
the level of testosterone and dihydrotestosterone in men, and estrogen in women. It also
inhibits follicle-stimulating hormone and leutenizing hormone.
Leuprolide is used for prostate cancer, when orchiectomy or estrogen therapy is counterproductive to the patient. A synonym of this drug is lupron.
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薬物相互作用
Leuprorelin acetate can not take with mang drugs, such as chasteberry, cisapride, dronedarone, pimozide, or thioridazine. This medicine may also interact with the following medications: herbal or dietary supplements, like black cohosh or DHEA; female hormones, like estrogens or progestins and birth control pills, patches, rings, or injections; male hormones, like testosterone; other medicines that prolong the QT interval (abnormal heart rhythm).
