寒天末

外観

白色〜黄灰色, 結晶性粉末～粉末

定義

本品は、マクサ Gelidium amansii, その他同属植物(Gelidiaceae)又は諸種の紅藻類(Rhodophyta)から得た粘液を凍結したものである。

溶解性

水に難溶 ＜0.1 g/100 mL at 17℃。熱水に徐々に溶ける。エタノール, ジエチルエーテルに難溶。水中に放置すると膨潤する。水、エタノール及びジエチルエーテルにほとんど溶けないが、水中に放置すると徐々に水を吸収して膨張する。試薬1ｇに水50mlを加えてかき混ぜながら加熱して溶かす。これを冷却すると弾力性のあるゼリーになる。

解説

寒天やカラギーナンなど、海藻類を原料とするゲル化剤。

用途

細菌培地の作成用。

用途

寒天橋、培養基剤。

用途

植物組織培養培地の作成用。

用途

細菌培養基剤

化粧品の成分用途

結合剤、親水性増粘剤、香料

化学的特性

Agar occurs as transparent, odorless, tasteless strips or as a coarse or fine powder. It may be weak yellowish-orange, yellowish-gray to pale-yellow colored, or colorless. Agar is tough when damp, brittle when dry.

天然物の起源

Agar is found in several species of red marine algae in oceans around the world.

使用

Agar is a gum obtained from red seaweeds of the genera gelidium, gracilaria, and eucheuma, class rhodophyceae. it is a mixture of the polysaccharides agarose and agaropectin. it is insoluble in cold water, slowly soluble in hot water, and soluble in boiling water, forming a gel upon cooling. the gels are characterized as being tough and brittle, setting at 32–40°c, and melting at 95°c. a rigid, tough gel can be formed at 0.5%. agar mainly functions in gel for- mation because of its range between melting and setting tempera- tures, being used in piping gels, glazes, icings, dental impression material, and microbiological plating. typical use levels are 0.1–2.0%.

調製方法

Agar is obtained by freeze-drying a mucilage derived from Gelidium amansii Lamouroux, other species of the same family (Gelidiaceae), or other red algae (Rhodophyta).

定義

agar: An extract of certain species ofred seaweeds that is used as a gellingagent in microbiological culturemedia, foodstuffs, medicines, andcosmetic creams and jellies. Nutrientagar consists of a broth made frombeef extract or blood that is gelledwith agar and used for the cultivationof bacteria, fungi, and somealgae.

一般的な説明

Tan powder.

空気と水の反応

Water insoluble.

反応プロフィール

Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. They exhibit both weak acid and weak base behavior.

火災危険

Flash point data for Agar are not available. Agar is probably combustible.

応用例（製薬）

Agar is widely used in food applications as a stabilizing agent. In pharmaceutical applications, agar is used in a handful of oral tablet and topical formulations. It has also been investigated in a number of experimental pharmaceutical applications including as a sustained-release agent in gels, beads, microspheres, and tablets.It has also been reported to work as a disintegrant in tablets.
Agar has been used in a floating controlled-release tablet; the buoyancy in part being attributed to air entrapped in the agar gel network.It can be used as a viscosity-increasing agent in aqueous systems. Agar can also be used as a base for nonmelting, and nondisintegrating suppositories.Agar has an application as a suspending agent in pharmaceutical suspensions.

安全性プロファイル

Mildly toxic by ingestion. When heated to decomposition it emits acrid smoke and fumes.

安全性

Agar is widely used in food applications and has been used in oral and topical pharmaceutical applications. It is generally regarded as relatively nontoxic and nonirritant when used as an excipient.
LD₅₀ (hamster, oral): 6.1 g/kg
LD₅₀ (mouse, oral): 16.0 g/kg
LD₅₀ (rabbit, oral): 5.8 g/kg
LD₅₀ (rat, oral): 11.0 g/kg

貯蔵

Agar solutions are most stable at pH 4–10.
Agar should be stored in a cool, dry, place. Containers of this material may be hazardous when empty since they retain product residues (dust, solids).

不和合性

Agar is incompatible with strong oxidizing agents. Agar is dehydrated and precipitated from solution by ethanol (95%). Tannic acid causes precipitation; electrolytes cause partial dehydration and decrease in viscosity of sols.

規制状況(Regulatory Status)

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral tablets). Included in the Canadian List of Acceptable Non-medicinal Ingredients. Included in nonparenteral medicines licensed in the UK.