基本属性 生物活性体外研究 用途与合成方法 供应商 供应信息 相关产品
网站主页 > 化工产品目录 > 生物化工 > 抑制剂 > 丝裂原活化蛋白激酶(MAPK) > Raf 抑制剂 > ZM 336372

ZM 336372

基本属性 生物活性体外研究 用途与合成方法 供应商 供应信息 相关产品
ZM 336372
ZM 336372 性质
  • 密度 1.298
  • 储存条件  -20°C
  • 溶解度 DMSO: >5mg/mL (warmed)
  • 颜色white to beige
  • 敏感性 Light Sensitive
ZM 336372 用途与合成方法
  • 生物活性ZM 336372是一种有效的,选择性的c-Raf抑制剂,IC50为70 nM,比作用于B-RAF选择性高10倍,对PKA/B/C, AMPK, p70S6等没有抑制作用。
  • 体外研究ZM 336372 shows 10-fold selectivity over B-Raf. ZM 336372 weakly inhibits SAPK2a/p38α and SAPK2b/p38β with IC50 of 2 μM, and is selective over 17 other protein kinases including PKA, PKC, AMPK, p42 MAPK, MKK1, SAPK1/JNK, and CDK1 even at the concentration of up to 50 μM. ZM 336372 does not prevent constitutive as well as growth factor or phorbol ester induced activation of MKKl or p42 MAPK/ERK2. Moreover, ZM 336372 dose not reverse the phenotype of Ras- or Raf-transformed cell lines. ZM 336372 treatment induces >100 activation of c-Raf and the B-Raf isoform, but it does not trigger any activation of MKKI or p42 MAPK/ERKP or induce any increase in the GTP-loading of Ras, suggesting that a feedback control loop exists by which Raf isoforms suppress their own activation, such that inhibition is always counterbalanced by reactivation. ZM 336372-induced activation of c-Raf is not prevented by inhibition of the MAPK cascade, protein kinase C or phosphatidylinositide 3-kinase. ZM 336372 (1 μM) abolishes the upregulation of eNOS after treatment with hydrogen peroxide. ZM 336372 treatment in carcinoid tumor cells results in progressive phosphorylation of Raf-1, mitogen-activated protein kinase 1/2, and extracellular signal-regulated kinase 1/2, and causes a significant reduction of bioactive hormone levels as well as the transcription factor, human achaete-scute homologue-1. Furthermore, ZM 336372 treatment leads to a marked suppression of cellular proliferation and induction of the cell cycle inhibitors p21 and p18. ZM 336372 inhibits the proliferation of pheochromocytoma cells, and suppresses NE vasoactive peptide production. ZM 336372 treatment in HepG2 induces the suppression of proliferation in a dose-dependent manner, suppression of hormone secretion, and up-regulation of cell cycle inhibitors. ZM 336372 also induces apoptosis in pancreatic adenocarcinoma cell lines by inhibiting glycogen synthase kinase-3β through phosphorylation of GSK-3β at Ser 9.
ZM 336372供应商更多
  • 公司名称:上海波以尔化工有限公司
  • 联系电话:86-15221043597
  • 产品介绍: 英文名称:ZM 336372
    CAS:208260-29-1
  •  
  • 公司名称:百灵威科技有限公司
  • 联系电话:400-666-7788 +86-10-82848833
  • 产品介绍: 英文名称:ZM 336372
    CAS:208260-29-1
    包装信息:2.5g,250Mg 备注:化学试剂、精细化学品、医药中间体、材料中间体
  •  
  • 公司名称:武汉易泰科技有限公司上海分公司
  • 联系电话:86-21-50328103 * 801、802、803、804 Mobile:18930552037
  • 产品介绍: 英文名称:ZM 336372;3-(DiMethylaMino)-N-[3-[(4-hydroxybenzoyl)-aMino]-4-Methylphenyl]benzaMide
    CAS:208260-29-1
    纯度:99% HPLC 包装信息:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
  •  
  • 公司名称:上海佰世凯化学科技有限公司
  • 联系电话:+86(0)21-20908456
  • 产品介绍: 英文名称:ZM 336372
    CAS:208260-29-1
    备注:C14484
  •  
  • 公司名称:上海源鼎化学科技有限公司
  • 联系电话:+86 (21) 5772-1279,+86 (21) 6775-2378
  • 产品介绍: 英文名称:3-(diMethylaMino)-N-(3-(4-hydroxybenzaMido)-4-Methylphenyl)benzaMide
    CAS:208260-29-1
    纯度:98% 包装信息:10g, 1kg, on request
  •  
最新发布供应信息
"ZM 336372"相关产品信息