3β-アセチルオキシ-16α-ヒドロキシ-24-メチレンラノスタ-8-エン-21-酸

使用

Pachymic Acid is a natural triterpene extract which suppresses invasiveness of pancreatic cancer cells through the downregulation of MMP-7.

抗がん研究

Extracted from Poria cocos, pachymic acid (PA) is a tri-terpenoid (a lanostanetype), which is reported to have anticancerous properties. NCI-H460 and NCI-H23cells, the lung cancer cell lines, were studied for the effect of pachymic acid.Expression of a major UPR target gene-regulated protein, CHOP, was upregulatedresulting in cell apoptosis after PA treatment. It was discovered that ROS inhibitorsblocked the ER stress activation induced by PA. The results indicated that ROSproduction is also regulated by PA in lung cancer cells (Cheng et al. 2015; Jun et al.2015). As per the studies conducted on MIA PaCa-2 and PANC-1 cell lines,PA-induced apoptosis in pancreatic cancer cell resistant to gemcitabine wasdependent on in vivo and in vitro activation of ER stress. PA can be exploited for itsanticancer effects for treatment of pancreatic cancer resistant to chemotherapy(Cheng et al. 2015).