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外観
うすい黄色～褐色, 結晶～粉末
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溶解性
ぎ酸に極めて溶けやすく、メタノールにやや溶けやすく、エタノール(99.5)にやや溶けにくく、水にほとんど溶けない。
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効能
血圧降下薬, 血管拡張薬, カルシウムチャネル遮断薬
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商品名
コニール (協和発酵キリン)
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説明
Benidipine hydrochloride is a new, long acting dihydropyridine calcium antagonist useful in the treatment of hypertension and angina pectoris. In experimental animals,
benidipine hydrochloride dose dependently induced hypotension with a potency of
6 and 12 times more than nifedipine and nicardipine, respectively. It also exhibited a
slow onset of action.
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化学的特性
Yellow Crystalline Powder
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使用
A dihydropyridine calcium channel blocker. Antihypertensive.
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生物活性
Orally active antihypertensive agent which displays a wide range of activities in vitro and in vivo . Inhibits L-, N- and T-type Ca 2+ channels. Also inhibits aldosterone-induced mineralocorticoid receptor activation. Exhibits cardioprotective and antiartherosclerotic effects.
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安全性プロファイル
A poison by ingestion,intraperitoneal, and intravenous routes. When heated todecomposition it emits toxic vapors of NOx and HCl.
