メシル酸ネルフィナビル

外観

白色～ほとんど白色粉末～結晶

用途

HIV プロテアーゼ阻害作用を 示します。

用途

強力な HIV-1 プロテアーゼ阻害剤です（Ki=2 nM）in vitro。経口活性があります。

用途

強力な HIV-1 プロテアーゼ阻害剤です（Ki=2 nmol/l in vitro）。経口活性があります。

効能

抗ウイルス薬, HIVプロテアーゼ阻害薬

商品名

ビラセプト (日本たばこ産業)

説明

Viracept was launched in the US as an orally-available, non-peptidic HIV protease inhibitor. It is prepared in an eight step synthesis beginning with N- (benzyloxycarbonyl)-L-serine β-lactone. The HIV protease inhibitory activity blocks the processing of gag and gagpol polyproteins that are required for viral maturation. It was discovered based on an experimentally derived 3D-structure of HIV-1 protease. Viracept has a high oral bioavailability, lacks toxicity, and has a resistance profile different from other protease inhibitors. Viracept with ziduvudine and larnivudine generated a 98% mean reduction from baseline in viral load after 24 weeks compared to ziduvudine and larnivudine alone. Viracept also had better CD4 counts and is available in adult and pediatric formulations.

化学的特性

White Powder

使用

Nelfinavir Mesylate is an antiviral. HIV protease inhibitor. It is a COVID19-related research product.

定義

ChEBI: A methanesulfonate (mesylate) salt prepared from equimolar amounts of nelfinavir and methanesulfonic acid. It is used for treatment of HIV and also exhibits some anticancer properties.

生物活性

Orally active human immunodeficiency virus protease inhibitor. Potently inhibits HIV-1 protease (K i = 2 nM) in vitro .