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外観
白色~わずかにうすい黄色, 結晶性粉末~粉末
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溶解性
熱水, メタノールに易溶。エタノール, 氷酢酸に難溶。エーテル, アセトン, ベンゼン, クロロホルムに不溶。熱水及び塩酸に溶け、アセトンにほとんど溶けない。
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解説
4-アミノフェニルアルソン酸,無色の針状晶.融点232 ℃.熱水から再結晶すると二水和物が得られるが,150 ℃ 以上で無水物となる.メタノールに易溶.ヒ素系医薬の製造原料となるほか,ジルコニウム,セリウムなどの検出試薬として使われる.
森北出版「化学辞典(第2版)
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用途
亜硝酸の検出、医薬原料。
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効能
抗菌薬 (獣医薬)
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化学的特性
off-white fine crystalline powder
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使用
4-Aminophenylarsonic acid is an organoarsenic compound. 4-Aminophenylarsonic acid is a highly toxic contaminant and can be found in plants growing in contaminated soil. 4-Aminophenylarsonic acid was used as an additive in animal feed. It has also been used in treating dysentery in swine as well as having potential chemotherapeutic activity.
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危険性
Toxic.
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健康ハザード
Occupational workers exposed to p-arsanilic acid develop poisoning. The symptoms
include, but are not limited to, eye and skin irritation, chemical conjunctivitis and corneal
damage, hyperpigmentation of the skin and, perkeratoses of plantar and palmar surfaces,
primary irritation and sensitization, digestive tract irritation, gastrointestinal hypermotility, diarrhea, hepatitis, hepatocellular necrosis, central nervous system depression, cardiac
disturbances, and liver and kidney damage. The target organs include the kidneys, central
nervous system, liver, and cardiovascular system. After a prolonged period of exposure
to arsenic compounds, including arsenical dust, workers are known to develop shortness
of breath, nausea, chest pains, garlic odor, and impairment of peripheral circulation. The
toxicological properties of p-arsanilic acid have not been fully investigated.
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安全性プロファイル
Poison by intravenous
and intraperitoneal routes. Moderately toxic
by ingestion. Flammable, decomposes with heat to yield flammable vapors. When
heated to decomposition or on contact with
acid or acid fumes it emits highly toxic
fumes of As and NO,. See also ARSENIC
COMPOUNDS and ANILINE.
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貯蔵
p-Arsanilic acid should be kept stored in a tightly closed container in a cool, dry, wellventilated area. It should be kept away from incompatible materials, dust generation,
excess heat, and strong oxidants.
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純化方法
Crystallise it from water or ethanol/ether. POISONOUS. [Beilstein 16 I 466.]
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予防処置
Occupational workers should wash thoroughly after using p-arsanilic acid. Any contaminated clothing should be washed before reuse. Work areas should have adequate ventilation and minimum dust generation and accumulation. Workers should avoid any
kind of contact of p-arsanilic acid with the eyes, skin, clothing, ingestion or inhalation.