ミデカマイシン

解説

ミデカマイシン，白色の結晶．融点155～156 ℃．[α]²⁰_D－65°(エタノール)．λmax 232 nm(ε 3250)．水，エタノールに可溶．LD50 7200 mg/kg(マウス，経口)．
森北出版「化学辞典（第2版）

ソース

ミデカマイシン，プラテノマイシン B1 ともいう．放線菌Streptomyces mycarofacienes，その他の培養液から得られるマクロライド系抗生物質．

応用

ミデカマイシン，主としてグラム陽性菌の発育を阻害する．肺炎球菌，ぶどう球菌，連鎖球菌などによる感染症治療薬として使用される．

効能

抗生物質, タンパク質合成阻害薬

説明

Midecamycin, a macrolide antibiotic having a 16-membered lactone ring, was found in the culture broth of Streptomyces mycarofaciens by Meiji Seika Kaisha in 1971. Under specific culture conditions, it is produced by the organism as a single component. Midecamycin shows almost the same antimicrobial spectrum and activity as kitasamycin. Although its serum and urine concentrations are low, it distributes in tissues at high concentration following oral administration.

化学的特性

White Solid

使用

A 16-membered ring macrolide antibiotic used in ophthalmology as well as other medical fields.

応用例（製薬）

A naturally occurring metabolite of Streptomyces mycarofaciens, supplied as the native compound and as midecamycin acetate for oral administration.
It is rapidly and extensively metabolized and is said to exhibit less toxicity than earlier macrolides. It is of limited availability.