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外観
白色～わずかにうすい褐色, 結晶～結晶性粉末
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溶解性
酢酸に溶ける。
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用途
カルボニル化合物の蛍光定量試薬、有機合成原料。
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使用上の注意
不活性ガス封入
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説明
2-Aminobiphenyl (2-APB) is an organic compound with the formula C6H5C6H4NH2. It is an amine derivative of biphenyl. It is a colorless solid, although aged samples can appear colored even black. Palladacycles obtained from 2-aminobiphenyl are popular catalysts for cross-coupling.
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化学的特性
colourless to purple crystalline solid. Soluble in alcohol, ether and benzene, insoluble in water. Can be volatilized with water vapor. Flash point >110℃.
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使用
2-Aminobiphenyl has a mutagenic potency. It is a substrate for UGTs (UDP-glucuronosyltransferases), including UGT1A4, UGT2B13 and UGT2B16.
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主な応用
2-Aminobiphenyl is used as raw materials for organic synthesis. manufacture of carbazole resin, synthetic rubber.
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製造方法
2-Aminodiphenyl is prepared by hydrogenation of 2-nitrobiphenyl.
NEW SYNTHESIS OF 2-AMINOBIPHENYLS
Reflux 2-nitrobiphenyl, ethanol and stannous chloride in a water bath for 3h, recover the ethanol, cool the residue, add 40% liquid alkali to make it strongly alkaline, separate the oil layer, extract the aqueous layer with ether, dry the extract with anhydrous calcium chloride, filter and recover the ether, wash with ethanol to obtain the crude product, then distill the crude product under reduced pressure to obtain 2-aminobiphenyl.
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一般的な説明
2-aminobiphenyl appears as colorless or purplish crystals. (NTP, 1992)
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空気と水の反応
Insoluble in water.
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反応プロフィール
2-Aminodiphenyl neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides.
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危険性
Toxic by ingestion, inhalation, and skin
absorption. A carcinogen.
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火災危険
2-Aminodiphenyl is probably combustible.
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安全性プロファイル
Moderately toxic by ingestion.Mutation data reported. When heated to decomposition, itemits toxic fumes of NOx.
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純化方法
Crystallise it from aqueous EtOH (charcoal). [Beilstein 12 IV 3223.]
