4-Chloro-1-butanol was employed as an internal standard in the analysis of genotoxic impurities in active pharmaceutical ingredients by GC-MS technique.
Tetramethylene chlorohydrin is used inorganic synthesis.
4-Chloro-1-butanol is employed as an internal standard in the analysis of genotoxic impurities in active pharmaceutical ingredients by GC-MS technique.
ChEBI: A primary alcohol that is butan-1-ol substituted by a chloro group at position 4.
4-Chloro-1-butanol, an alkylating agent, is one of the genotoxic impurity in active pharmaceutical ingredients. Reaction of 4-chloro-1-butanol and Reichardt′s dye has been monitored spectrophotometrically for the determination of genotoxic impurities in pharmaceuticals.
The toxicity of this compound is low. How ever, the acute toxic symptoms are those ofethylene and propylene chlorohydrins. Oralintake of this compound caused muscle con traction, gastrointestinal pain, ulceration, andliver injury in test animals.
LD50 value, oral (mice): 990 mg/kg
Tetramethylene chlorohydrin caused tumorsin lungs in test animals. Its carcinogenicity,however, is not yet fully established.
Flammable; flash point 36°C (97°F); vapor
density 3.7 (air = 1); the vapor forms an
explosive mixture with air, range is not
reported. Fire-extinguishing agent: “alcohol”
foam; a water spray may be used to cool fire-exposed containers and to flush any spill. It
decomposes to HCl and tetrahydrofuran on
heating.
Moderately toxic by
ingestion. Questionable carcinogen with
experimental neoplastigenic data. Mutation
data reported. When heated to
decomposition it emits toxic fumes of Cl-.
See also CHLORIDES and ALCOHOLS.
Tetramethylene chlorohydrin is burned ina chemical incinerator equipped with anafterburner and scrubber.
