セファロリジン

効能

抗生物質, 細胞壁合成阻害薬

使用

Antibacterial agent.

定義

ChEBI: A cephalosporin compound having pyridinium-1-ylmethyl and 2-thienylacetamido side-groups. A first-generation semisynthetic derivative of cephalosporin C.

世界保健機関（WHO）

Cefaloridine, a semi-synthetic cephalosporin antibiotic, was introduced into medicine in 1964 for the treatment of bacterial infections. It is considered to be the most toxic of the cephalosporins, and for this reason is now seldom used. Nevertheless, it still remains available in certain countries and the World Health Organization is not aware of restrictive actions taken elsewhere.

一般的な説明

Cephaloridine, along with cephalothin, was the first member of the synthetic cephalosporin C class of antibiotic, to be introduced clinically. It was synthesized, starting with 7-aminocephalosporanic acid, by Glaxo Research Laboratories in 1962. This drug shows strong activity against gram-positive and gramnegative bacteria and Leptospira, including benzylpenicillin-resistant strains. It has been given widely by intravenous, intramuscular, and intraspinal injection to treat a variety of infections caused by Staphylococcus, Streptococcus, Neisseria, Klebsiella, Escherichia coli, and other pathogens. Because of its renal toxicity and the development of newer and more active synthetic cephalosporins, its use is declining.

危険性

Moderately to very toxic.