チオ酢酸

外観

無色～黄褐色, 澄明の液体

溶解性

水及びエタノールに極めて溶けやすい。水に可溶。エタノール、エーテルに易溶。

解説

チオ酢酸．酢酸のO 1個をSで置換したもの．チオール形とチオン形が考えられるが，赤外吸収ではチオール形のみとみられる．無水酢酸と硫化水素とを少量の水酸化カリウムの存在下に反応させてつくる．

融点－17 ℃，沸点87 ℃．d²⁰₄ 1.069．エタノール，エーテルに可溶．

用途

希アンモニア水に溶かして硫化水素と同様に金属沈殿試薬として用いる。

化学的特性

colourless fuming liquid with an unpleasant odour

使用

Thioacetic acid is a reagent for introduction of the thiol group into organic molecules. It is used as flavor & Fragrance Intermediates. It is used to manufacture captopril(antihypertension) and spironolac-tone (diuretic).

定義

ChEBI: A thioacetic acid that is acetic acid in which the oxygen atom of the hydroxy group has been replaced by a sulfur atom.

一般的な説明

A clear,yellow liquid with a strong, unpleasant odor. May be toxic by ingestion, inhalation and skin absorption. Irritating to skin and eyes. Flash point near 50°F. Used to make other chemicals.

空気と水の反応

Highly flammable. Water soluble.

反応プロフィール

Thioacetic acid is a thio organic acid. Organosulfides are incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Many of these compounds may liberate hydrogen sulfide upon decomposition or reaction with an acid.

危険性

Toxic by ingestion and inhalation; strong irritant to eyes and skin.

健康ハザード

May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

火災危険

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

安全性プロファイル

Poison by intraperitoneal route. A very dangerous fire hazard when exposed to heat or flame. When heated to decomposition it emits toxic fumes of SOx. See also SULFIDES and MERCAPTANS.