2,2-ジメチル-3-(2-メチル-1-プロペン-1-イル)-1-シクロプロパンカルボン酸2-メチル-4-オキソ-3-(2-プロピニル)-2-シクロペンテン-1-イル

化学的特性

solid

使用

Prallethrin ia a synthetic pyrethroid; propynyl analog of allethrin. Prallethrin is used as an insecticide.

危険性

A poison by ingestion and inhalation. Low toxicity by skin contact.

薬理学

Prallethrin is a propynyl analog of allethrin, with 2-methyl-4-oxo-3-(prop-2-ynyl)-cyclopent-2-enyl as the secondary alcohol moiety that has been introduced against public health pests (113–115). The ester of the (S)-alcohol with (1R)-trans,cis-chrysanthemic acid resolved partially is commercialized on the strength of the assessment of insecticidal action of individual stereoisomers (116). Compared with d-allethrin, it is approximately four, six, and five times more effective on Musca domestica (for killing), Blattella germanica (for killing), and Culex pipiens pallens (for knockdown), respectively (43). A lower level of resistance to prallethrin than to phenoxybenzyl pyrethroids was demonstrated in a kdr-resistant housefly strain (116).

安全性プロファイル

A poison by ingestion and inhalation. Low toxicity by skin contact. When heated to decomposition it emits acrid smoke and irritating vapors.

代謝経路

Prallethrin is stable under normal room temperature storage conditions for up to 36 months. It is labile to alkali at the ester linkage, forming 2 and 3 (Scheme 1). Analogy with the allethrins (from which it differs only in the degree of unsaturation in the side chain - propyne rather than propene) would suggest that the compound is very photolabile.