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外観
白色～わずかにうすい黄色又はわずかにうすい赤色, 結晶性粉末～粉末
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溶解性
水及びエタノールに溶け、アセトンにほとんど溶けない。
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用途
肺胞表面活性代謝物の分泌を
増加します。
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用途
スーパーオキシドディスムターゼ(SOD)の研究。
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効能
去痰薬, 粘液溶解薬
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商品名
アンブロキソール塩酸塩 (ローマン工業); アンブロキソール塩酸塩 (高田製薬); アンブロキソール塩酸塩 (高田製薬); アンブロキソール塩酸塩 (高田製薬); ムコサール (サノフィ); ムコソルバン (帝人ファーマ); ムコソルバン (帝人ファーマ); ムコソルバン (帝人ファーマ); ムコソルバン (帝人ファーマ); ムコソルバン (帝人ファーマ); ムコソルバン (帝人ファーマ)
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化学的特性
White Crystalline Powder
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定義
ChEBI: Ambroxol hydrochloride is an aromatic amine. it is a metabolite of bromhexine that stimulates mucociliary action and clears the air passages in the respiratory tract. it is usually administered as the hydrochloride.
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適応症
Ambroxol Hydrochloride is a bronchosecretolytic drug. It is indicated as “secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport. It promotes mucus clearance, facilitates expectoration and eases productive cough, allowing patients to breathe freely and deeply.
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生物活性
Sodium channel blocker and mucolytic agent with antioxidant, anti-viral and anti-inflammatory properties. Inhibits tetrodotoxin (TTX)-resistant channels more potently than TTX-sensitive subtypes (IC 50 values for tonic block are 35.2 and 111.5 μ M respectively). Inhibits release of histamine, leukotrienes and cytokines from human leukocytes and mast cells.
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Mode of action
Ambroxol is the active metabolite of bromhexine. Ambroxol causes an increase in secretion in the respiratory tract. It promotes surfactant production and stimulates ciliary activity. These effects assist the flow of mucus and its removal (mucociliary clearance). An improvement in mucociliary clearance was demonstrated in clinical pharmacological studies. The increase in secretion and mucociliary clearance facilitate expectoration and reduce the cough. In in vitro studies ambroxol showed a significant reduction in cytokine release, both in the blood and in mononuclear and polynuclear cells. The clinical relevance of these findings is unclear.
