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外観
白色〜わずかにうすい黄色, 粉末
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溶解性
水に溶けやすく、エタノール(95)に極めて溶けにくい。
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用途
酢酸菌や好熱菌などから酵素精製の際の除核酸、遺伝子工学研究用。
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用途
アミノグリコシド系抗生物質
です。細菌リボソーム 30S に結合し、タン
パク質合成阻害作用を示します。グラム陽性・
陰性菌に対して抗菌力を示します。
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効能
抗結核薬, 抗生物質, タンパク質合成阻害薬
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商品名
硫酸ストレプトマイシン (Meiji Seikaファルマ)
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説明
Streptomycin was found in the culture broth of Streptomyces griseus by S. A. Waksman of Rutgers University in 1944; it was the second antibiotic introduced clinically (after penicillin). This drug is a water soluble, basic substance having an aminoglycoside structure and showing strong activity against a wide range of gram-positive and gram-negative bacteria including Mycobacterium. Streptomycin is the first choice among antituberculotic antibiotics and has been used for the therapy of Spirochaeta and Treponema infections.
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化学的特性
White to off-white powder
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使用
Streptomycin sulfate is a sulfate salt of streptomycin that is a protein synthesis inhibitor. Streptomycin is an antibiotic drug, the first of a class of drugs called aminoglycosides to be discovered, and was the first antibiotic remedy for tuberculosis.
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一般的な説明
An antibacterial. White to light gray or pale buff powder with faint amine-like odor.
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空気と水の反応
Hygroscopic. Water soluble.
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反応プロフィール
Streptomycin sulfate is a medicinal amino saccharide.
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健康ハザード
SYMPTOMS: Symptoms of exposure to Streptomycin sulfate include skin rashes, eosinophilia, blood dyscrasias, stomatitis, anaphylactic shock, pruritus, scaling, and fever.
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火災危険
Flash point data for Streptomycin sulfate are not available, however Streptomycin sulfate is probably combustible.
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安全性プロファイル
Poison by ingestion and intravenous routes. Moderately toxic by subcutaneous route. An experimental teratogen. Human systemic effects by intraperitoneal route: flaccid paralysis without anesthesia, motor activity changes and pulmonary changes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SOx. See also STREPTOMYCIN and SULFATES.
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純化方法
The sulfate is recrystallised from H2O/EtOH, washed with a little EtOH, Et2O and dried in a vacuum. [UV and IR: Grove & Randall Antibiotics Monographs 2 163 1855, Heuser et al. J Am Chem Soc 75 4013 1953, Kuehl et al. J Am Chem Soc 68 1460 1946, Regna et al. J Biol Chem 165 631 1946.] During protein synthesis it inhibits initiation and causes misreading of mRNA [Zierhut et al. Eur J Biochem 98 577 1979, Chandra & Gray Methods Enzymol 184 70 1990]. [Beilstein 18/11 V 82.]
