-
外観
白色~わずかにうすい褐色, 結晶性粉末~粉末
-
溶解性
アセトン,ジオキサンにやや可溶、メタノール,クロロホルムに難溶、水,エーテルにほとんど不溶。エタノールに溶け、水にほとんど溶けない。
-
用途
薬理研究用。
-
用途
トリアムシノロン(Triamcinolone)は長時間作用型の合成コルチコステロイド(ステロイド剤)の一種。
トリアムシノロンのようなコルチコステロイドは、免疫系において重要な役割を果たすある種の化学物質の放出を阻害するよう細胞に作用し、炎症を和らげる。
トリアムシノロンは血液中の白血球の数を減少させる効果もあるとされる。これは白血球が異常に多く作られてしまう型の白血病の治療に有効である。また、免疫系が自らの体の組織を攻撃してしまう自己免疫疾患の治療にも用いられる。
-
用途
副腎皮質ホルモン剤です。糖
質コルチコイドにフッ素を付加することで
で、糖質コルチコイド作用を強めています。
-
効能
喘息治療薬, 抗炎症薬, 抗リウマチ薬, グルココルチコイド受容体作動薬
-
商品名
アフタシール (帝國製薬); アフタッチ (帝人ファーマ); ケナコルト−A (ブリストル・マイヤーズスクイブ); ケナコルト−A (ブリストル・マイヤーズスクイブ); マキュエイド (わかもと製薬); レダコート (アルフレッサファーマ); ワプロン (救急薬品工業)
-
説明
Triamcinolone acetonide is a synthetic corticosteroid. It decreases cytokine levels, the firing rate of sensory neurons, and mechanical hypersensitivity in a rat spinal nerve ligation model when used at a dose of 1.5 mg/kg prior to and following surgery for three days. Triamcinolone acetonide also decreases outflow facility in a mouse model of steroid-induced glaucoma when 20 μl of a 40 mg/ml suspension is administered subconjunctivally. Formulations containing triamcinolone acetonide are used in the treatment of diabetic macular edema.
-
化学的特性
White Solid
-
定義
ChEBI: A synthetic glucocorticoid that is the 16,17-acetonide of triamcinolone. Used to treat various skin infections.
-
適応症
Triamcinolone acetonide (Aristocort, Kenalog) is a synthetic fluorinated corticosteroid.
-
一般的な説明
The three main metabolitesof triamcinolone acetonide (Azmacort, Nasacort) are 6β-hydroxytriamcinolone acetonide, 21-carboxytriamcinoloneacetonide, and 6β-hydroxy-21-carboxytriamcinolone acetonide.All are much less active than the parent compound.The 6β-hydroxyl group and the 21-carboxy group are bothstructural features that greatly reduce GC action. The increasedwater solubility of these metabolites also facilitatesmore rapid excretion.
-
臨床応用
Triamcinolone acetonide used topically to treat various skin conditions, to relieve the discomfort of mouth sores, and by injection into joints to treat various joint conditions.Triamcinolone acetonide frequently is used by inhalation for the treatment of lung diseases (e.g., asthma).
-
副作用
The side effects of using Triamcinolone acetonide include:Skin dryness, flaking, crusting, burning, or blistering; Skin irritation; Skin soreness, itching, swelling, scaling, or severe redness; Scaling or redness near mouth; Skin thinning or bruising, especially in skin folds (like between the finger) or on the face (when directed to use it there); New or worsening pimples or acne; Skin burning and itching with tiny red blisters; Skin softening; Itching, pain, or burning sensation in hairy areas, or pus at the root of the hair; Increased hair growth on the legs, arms, back, or forehead; Lightening of skin tone; Red or purple lines on the arms, face, legs, groin, or trunk.
-
安全性プロファイル
Poison by
subcutaneous and intraperitoneal routes.
An experimental teratogen. Other
experimental reproductive effects. Human
mutation data reported. When heated to
decomposition it emits acrid smoke and
toxic fumes of F-.
-
代謝
Triamcinolone acetonide frequently is used by inhalation for the treatment of lung diseases (e.g., asthma). After
inhalation, triamcinolone acetonide can become systemically available when the inhaled formulation is
swallowed and absorbed unchanged from the GI tract, causing undesirable systemic effects.
Triamcinolone acetonide that is swallowed is metabolized to 6β-hydroxytriamcinolone acetonide,
21-carboxytriamcinolone acetonide, and 21-carboxy-6β-hydroxytriamcinolone acetonide, all of which are more
hydrophilic than their parent drug. Only approximately 1% of the dose was recovered from the urine as
triamcinolone acetonide. Triamcinolone is not a major metabolite of triamcinolone acetonide in humans,
suggesting that acetonide is resistant to hydrolytic cleavage. Triamcinolone acetonide is approximately eight
times more potent than prednisolone.