2-オクチルドデカン-1-オール

外観

無色～ほとんど無色透明液体

定義

本品は、次の化学式で表される脂肪族アルコールである。

用途

トリートメント / コンディショナー,クレンジング,化粧水 / 乳液 / クリーム,ファンデーション / 下地,口紅 / グロス,アウトバスヘアケア,UVケア

原料由来

液状高級脂肪酸/液状高級アルコール（植物系のみ）

化粧品の成分用途

エモリエント剤、香料

特徴

ほぼ無色無臭で、植物由来の分枝鎖飽和アルコール。優れた加熱安定性。水添ポリイソブテンの使用感改良に優れた効果を発揮。

化学的特性

2-Octyl-1-dodecanol is clear, colourless or yellowish, oily liquid.

使用

2-Octyl-1-dodecanol have been used as a emulsion stabilizer for polymer matrix patches.

調製方法

2-Octyl-1-dodecanol is produced by the condensation of two molecules of decyl alcohol. It also occurs naturally in small quantities in plants.

一般的な説明

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

応用例（製薬）

Octyldodecanol is widely used in cosmetics and pharmaceutical applications as an emulsifying and opacifying agent. It is primarily used in topical applications because of its lubricating and emollient properties.
Octyldodecanol has been used in the preparation of oil/water microemulsions investigated as the vehicle for the dermal administration of drugs having no or low skin penetration.Octyldodecanol has also been evaluated as a solvent for naproxen when applied topically.Studies of estimated permeability coefficient suggest that octyldodecanol could be a potential dermal permeation enhancer.

安全性プロファイル

An eye and severe skin irritant.When heated to decomposition it emits acrid smoke andirritating vapors.

安全性

Octyldodecanol is widely used in cosmetics and topical pharmaceutical formulations, and is generally regarded as nontoxic and nonirritant at the levels employed as an excipient.
In acute oral toxicity studies in rats fed 5 g/kg of undiluted octyldodecanol, no deaths were observed.In an acute dermal toxicity study, intact and abraded skin sites of guinea pigs were treated with 3 g/kg of undiluted octyldodecanol under occlusive patches; no deaths occurred and no gross skin lesions were observed.Octyldodecanol caused either no ocular irritation or minimal, transient irritation in the eyes of rabbits.However, some sources describe undiluted octyldodecanol as an eye and severe skin irritant.

貯蔵

The bulk material should be stored in a well-closed container in a cool, dry place, protected from light. In the original unopened container, octyldodecanol can be stored for 2 years protected from moisture at below 30°C.

不和合性

2-Octyl-1-dodecanol is generally compatible with most materials encountered in cosmetic and pharmaceutical formulations.

規制状況(Regulatory Status)

Included in the FDA Inactive Ingredients Database (topical, transdermal, and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.