基本属性 生物活性靶点体外研究体内研究 用途与合成方法 六氢姜黄素 价格(试剂级) 供应商 供应信息 相关产品
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六氢姜黄素

六氢姜黄素

中文名称:六氢姜黄素
英文名称:HEXAHYDROCURCUMIN
CAS号:36062-05-2
分子式:C21H26O6
分子量:374.43
EINECS号:
Mol文件:36062-05-2.mol
六氢姜黄素 结构式

六氢姜黄素 性质

熔点 80-82℃
沸点 622.6±55.0 °C(Predicted)
密度 1.226
闪点 218℃
储存条件 2-8°C
溶解度 可溶于氯仿(少量)、乙酸乙酯(少量)、DCM、DMSO
酸度系数(pKa) 10.02±0.20(Predicted)
颜色 淡黄色低
BRN 2486876

六氢姜黄素 用途与合成方法

Hexahydrocurcumin 是姜黄素的主要代谢产物之一,是一种选择性的口服活性 COX-2 抑制剂,对 COX-1 无活性。Hexahydrocurcumin 具有抗氧化,抗癌和抗炎的作用。

COX-2

Hexahydrocurcumin (0-25 μM; 24-48 hours; HT-29 cells) treatment significantly decreased the viability of HT-29 colon cancer cells in a time- and concentration-dependent. The respective IC 50 values for 24 and 48 h of Hexahydrocurcumin exposureare 77.05 and 56.95, respectively.
Hexahydrocurcumin (0-25 μM; 24-48 hours; HT-29 cells) combined with 5-fluorouracil (5-FU; 5 µM) markedly reduces the COX-2 expression. The level of COX-1 is not altered.
Hexahydrocurcumin (0-25 μM; 24-48 hours; HT-29 cells) combined with 5-fluorouracil (5-FU; 5 µM) markedly reduces the COX-2 protein. The level of COX-1 protein is not altered.
Hexahydrocurcumin (7-14 μM; 24 hours) attenuates lipopolysaccharide (LPS)-elicited increase of prostaglandin E 2 (PGE 2 ) in murine macrophages (RAW 264.7) in a concentration-dependent manner.

Cell Viability Assay

Cell Line: HT-29 cells
Concentration: 0 µM, 5 µM, 10 µM, 25 µM
Incubation Time: 24 hours or 48 hours
Result: Significantly decreased the viability of HT-29 colon cancer cells.

RT-PCR

Cell Line: HT-29 cells
Concentration: 25 µM
Incubation Time: 24 hours
Result: Combined with 5-fluorouracil (5-FU; 5 µM) markedly reduced the COX-2 expression.

Western Blot Analysis

Cell Line: HT-29 cells
Concentration: 25 µM
Incubation Time: 24 hours
Result: Combined with 5-fluorouracil (5-FU; 5 µM) markedly reduced the COX-2 protein.

Hexahydrocurcumin (50 mg/kg; oral administration; daily; for 16 weeks; male Wistar rats) treatment significantly reduces the numbers of aberrant crypt foci (ACF) in colon cancer rats. Hexahydrocurcumin also markedly decreases COX-2 protein expression. The levels of COX-1 protein is not different from normal rats.

Animal Model: Male Wistar rats (100-120 g) injected with dimethylhydrazine (DMH)
Dosage: 50 mg/kg
Administration: Oral administration; daily; for 16 weeks
Result: Significantly reduced the numbers of ACF in colon cancer rats. Also markedly decreased COX-2 protein expression.

安全信息

WGK Germany3

六氢姜黄素 价格(试剂级)

更新日期 产品编号 产品名称 CAS号 包装 价格
2024-01-25 HY-N0929 1 mg 1309
2024-01-25 HY-N0929 六氢姜黄素 36062-05-2 5mg 3600

六氢姜黄素供应商 更多

云南西力生物技术股份有限公司
黄金产品
联系电话:0871-65217109 13211707573;
产品介绍:
中文名称:六氢姜黄素
英文名称:Hexahydrocurcumin
CAS:36062-05-2
纯度:98.0%
包装信息:5mg
备注:BBP02527
成都普思生物科技股份有限公司
现货
联系电话:028-85370565-229 18080489829
产品介绍:
中文名称:六氢姜黄素
英文名称:Hexahydrocurcumin
CAS:36062-05-2
纯度:98.0%(HPLC)
包装信息:10mg
备注:现货供应,当天发货
库存量:5000mg
现货日期:2024/3/27 11:54:41
上海佰世凯化学科技有限公司
联系电话:021-20908456
产品介绍:
中文名称:六氢姜黄素
英文名称:HexahydrocurcuMin
CAS:36062-05-2
纯度:98%
包装信息:5mg;10mg;50mg;100mg;500mg
备注:C11084
成都普瑞法科技开发有限公司
联系电话:+86-028-82633397 18982077548
产品介绍:
中文名称:六氢姜黄素
英文名称:Hexahydrocurcumin
CAS:36062-05-2
纯度:>95%,98%,99%
包装信息:From mgs to grams,up to Kgs.Inquire for Bulk scale.
备注:可以大量定制
上海同田生物技术有限公司
联系电话:021-51320588
产品介绍:
英文名称:HexahydrocurcuMin
CAS:36062-05-2
纯度:NLT 95% HPLC
包装信息:10Mg;20Mg;50Mg;100Mg to graMs.Not More than tens of graMs.
备注:H004

最新发布供应信息

COX-2抑制剂(Hexahydrocurcumin)
上海泽叶生物科技有限公司 2024-03-28
六氢姜黄素
四川省维克奇生物科技有限公司 2024-03-25

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