Basic information General Physical and chemical properties Local anesthetic and antiarrhythmic drugs Application Metabolism Indications Usage and dosage Adverse effect Additional information Medicine interactions Precautions References Safety Related Supplier
Lidocaine hydrochloride Structure

Lidocaine hydrochloride

Chemical Properties

Melting point 80-82°C
storage temp.  Inert atmosphere,2-8°C
Water Solubility  Water : ≥ 36 mg/mL (132.94 mM)
InChI InChI=1S/C14H22N2O.ClH/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4;/h7-9H,5-6,10H2,1-4H3,(H,15,17);1H
InChIKey IYBQHJMYDGVZRY-UHFFFAOYSA-N
SMILES C(NC1=C(C)C=CC=C1C)(=O)CN(CC)CC.[H]Cl
LogP 2.359 (est)
CAS DataBase Reference 73-78-9(CAS DataBase Reference)
EPA Substance Registry System Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-, monohydrochloride (73-78-9)
Lidocaine hydrochloride is a local anesthetic and antiarrhythmic drug. It is clinically used for infiltration anesthesia, epidural anesthesia, surface anesthesia (including in the thoracoscopy or abdominal surgery for mucosal anesthesia) and nerve conduction block. The drug can also be used for acute myocardial infarction after ventricular premature beats and ventricular tachycardia, and for digitalis poisoning, cardiac surgery and ventricular arrhythmias caused by cardiac catheterization. But it is usually ineffective for supraventricular arrhythmias.

Safety Information

RIDADR  3249
HazardClass  6.1(b)
PackingGroup  III
Toxicity LD50 oral in mouse: 220mg/kg

Usage And Synthesis

Preparation Products And Raw materials

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