D-パントテン酸カルシウム

外観

白色の粉末

定義

本品は、パントテン酸(*)のカルシウム塩であり、次の化学式で表される。
参照表示名称：パントテン酸

溶解性

水に易溶, エタノールに難溶, エーテルに不溶。水に溶けやすく、エタノールに極めて溶けにくく、ジエチルエーテルにほとんど溶けない。

解説

パントテン酸カルシウム，水溶性ビタミンで，補酵素の構成成分である。生体内に取込まれると組織細胞中でコエンザイムA (CoA) に生合成される。動物実験では，欠乏の際に成長停止，毛髪，神経，消化管，副腎などの障害が認められる。腸内細菌により生成されるので，抗生物質投与により腸内細菌が死滅したような場合に欠乏症をきたす可能性がある。臨床的には成育期，妊娠時，病後回復期などに投与され，また，放射線療法，抗腫瘍剤，ストレプトマイシンなどの副作用防止に用いられる。副作用としては，1日 10～20gを内服で連続投与すると下痢，顔面浮腫などの症状を示すが，投薬を中止すれば消失する。

用途

保健機能食品（栄養機能食品）
栄養機能食品は、栄養成分の機能の表示をして販売される食品です。栄養機能食品として販売するためには、一日当たりの摂取目安量に含まれる当該栄養成分量が定められた上?下限値の範囲内にある必要があるほか、栄養機能表示だけでなく注意喚起表示等も表示する必要があります。 栄養機能表示
パントテン酸は、皮膚や粘膜の健康維持を助ける栄養素です。 注意喚起表示
本品は、多量摂取により疾病が治癒したり、より健康が増進するものではありません。1日の摂取目安量を守ってください。

用途

ビタミン B 群化合物です。代 謝反応に作用します。

用途

薬理研究用。生理作用研究用。

化粧品の成分用途

ヘアコンディショニング剤

効能

パントテン酸補充薬

商品名

パントテン酸カルシウム (丸石製薬)

使用上の注意

吸湿性あり

化学的特性

Calcium D-Pantothenate is white crystalline powder

来歴

Pantothenic acid (PA), also known as vitamin B5, is essential to all forms of life. Its name is derived from the Greek word pantos that means “everywhere”, which is appropriate for this widely, distributed vitamin.

使用

D-(+)-Pantothenic acid calcium salt is a member of the B complex vitamins; essential vitamin for the biosynthesis of coenzyme A in mammalian cells. Occurs ubiquitously in all animal and plant tissue. The richest common source is liver, but jelly of the queen bee contains 6 times as much as liver. Rice bran and molasses are other good sources.

定義

Calcium pantothenate, also known as calcium D-pantothenate or calcium pantothenic acid, is a naturally occurring form of pantothenic acid, an essential vitamin found in various foods. Calcium pantothenate is generally recognized as safe (GRAS) in the United States and in Europe. The US FDA requires infant formulas have at least 300 micrograms (mcg) per 100 calories of prepared formula.

反応性

Pantothenic acid is a constituent of coenzyme A, which participates in numerous enzyme reactions. CoA was discovered as an essential cofactor for the acetylation of sulfanilamide in the liver and of choline in the brain.

生物学の機能

Calcium D-Pantothenate accelerates the wound healing process by increasing the number of migrating cells, their distance and hence their speed.  In addition, cell division is increased and the protein synthesis changed.   Hence, higher quantities of pantothenate are locally required to enhance wound healing.

一般的な説明

The first suggestion for the existance of vitamin B₅ came from Carter et al. in 1930; although it was never characterized or isolated. This vitamin is synthesized by most green plants and microorganisms. Excellent sources of the vitamin are liver, egg yolk, whole grains, and fortified ready-to-eat cereals. However, as the original name implies, many foods contain sufficient pantothenic acid to supply dietary needs.
Chemically, pantothenic acid is considered to be aβ-alanine derivative of the asymmetric pantoic acid and thus shows asymmetry. Only the naturally occurring D(+)- stereoisomer (with R configuration) is biologically active and the L(-)-stereoisomer (with S configuration) is inactive. When its carboxylate functional group is attached through an amide linkage with β-mercaptoethylamine, it is known as pantetheine (also spelled pantotheine). The biologically active form of pantothenic acid, CoA, is formed when the terminal alcoholic function of pantetheine is attached to ADP 3'-phosphate.

臨床応用

The only therapeutic indication for pantothenic acid is intreatment of a known or suspected deficiency of this vitamin.Because of the ubiquitous nature of pantothenic acid, deficiencystates of this vitamin are only seen experimentally byuse of synthetic diets devoid of the vitamin, by use of thevitamin antagonist, ω-methylpantothenic, or both. In a 1991review, Tahiliani and Beinlich described that the mostcommon symptoms associated with pantothenic acid deficiencywere headache, fatigue, and a sensation of weakness.Sleep disturbances and gastrointestinal disturbances, amongothers, were also noted. The most likely setting for pantothenicacid deficiency is in the setting of alcoholism wherea multiple vitamin deficiency exists confounding the exactrole of the pantothenic acid deficiency as compared to theother vitamins. Because a deficiency of a single B vitamin israre, pantothenic acid is commonly formulated in multivitaminor B-complex preparations.

安全性プロファイル

Moderately toxic by intraperitoneal, subcutaneous, and intravenous routes. Mildly toxic by ingestion. A vitamin. See also CALCIUM COMPOUNDS. When heated to decomposition it emits toxic fumes of NOx.

純化方法

The salt crystallises as needles from MeOH, EtOH or isoPrOH (with 0.5mol of isoPrOH). It is moderately hygroscopic. The S-benzylisothiuronium salt has m 151-152o (149o when crystallised from Me2CO). [Kagan et al. J Am Chem Soc 79 3545 1957, Wilson et al. J Am Chem Soc 76 5177 1954, Stiller & Wiley J Am Chem Soc 63 1239 1941, Beilstein 4 IV 2569.]