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解説
ニアラミド，白色の結晶．融点152～153 ℃．酸性溶媒に易溶，水に難溶．わずかに苦味がある．LD50 1000 mg/kg(マウス，経口)．
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用途
ニアラミド，モノアミンオキシダーゼ阻害作用があり，抗うつ薬に用いられる．
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製造
1-イソニコチノイル-2-(2-メトキシカルボニルエチル)ヒドラジンとベンジルアミンとの反応で得られるニアラミド．
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効能
抗うつ薬, モノアミン酸化酵素(MAO)阻害薬
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化学的特性
White, crystalline powder. Low solubility in water; good solubility in slightly acid solution. It is stable in crystalline form, suspension, and
solution.
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使用
Nialamide is a nonselective monoamine oxidase (MAO) inhibitor that is used as an antidepressant.
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世界保健機関（WHO）
Nialamide, a monoamine oxidase inhibitor (MAOI), was
introduced in 1959 for the treatment of depressive illness. Subsequently concern
regarding potentially serious interactions between MAOIs and foods containing
tyramine inspired much restrictive regulatory action. However, MAOIs still retain a
place in the treatment of serious depressive illness although there is no
international consensus on which compounds should be preferred. Thus nialamide
remains available in several countries.
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一般的な説明
Nialamide is an antidepressant drug and its effect on β-adrenergic receptor-adenylate cyclase system of rat pineal gland has been studied. Antidepressant action of the combination of nialamide and 5-hydroxytryptophan has been evaluated.
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危険性
Toxic in overdose.
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安全性プロファイル
Poison by intravenous andintraperitoneal routes. Moderately toxic by ingestion.Mutation data reported. Experimental reproductiveeffects. An antidepressant. When heated to decompositionit emits toxic fumes of NOx.
