亚牛磺酸
亚牛磺酸 性质
| 熔点 | 175-177 °C |
|---|---|
| 沸点 | 354.9±44.0 °C(Predicted) |
| 密度 | 1.511±0.06 g/cm3(Predicted) |
| 储存条件 | Desiccate at RT |
| 溶解度 | H2O:100 mg/mL |
| 形态 | 固体 |
| 酸度系数(pKa) | 2.54±0.10(Predicted) |
| 颜色 | 白色 |
| 水溶解性 | Soluble to 100 mM in water |
| LogP | -2.030 (est) |
| CAS 数据库 | 300-84-5(CAS DataBase Reference) |
| EPA化学物质信息 | Hypotaurine (300-84-5) |
亚牛磺酸 用途与合成方法
亚牛磺酸是牛磺酸的前体之一，经过氧化变为牛磺酸，哺乳动物主要通过这条途径合成，而合成牛磺酸的氧化酶是一个非限速的，所以可以保持一个平衡。晶体的溶解度只有6－7％，亚牛磺酸钠要高一些。
自1975年Hayes等报道，缺乏牛磺酸会导致幼猫视功能减退甚至失明后，人们对牛磺酸的营养作用越来越关注。
先在发现的牛磺酸功能很多，但主要是促进细胞膜对糖的吸收，此外还可作用于胰岛素受体，发挥胰岛素样效应。 Hypotaurine (2-aminoethanesulfinic acid) 是星形胶质细胞中半胱氨酸的牛磺酸生物合成中间体，是甘氨酸受体 (glycine receptor) 的内源性抑制性氨基酸。
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Human Endogenous Metabolite
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Hypotaurine and taurine are found to reside within the cytosolic compartment of the cell. The ratio of taurine to hypotaurine is approx 50:1. The cytosolic concentration of taurine is approx. 50 mM. The concentration of hypotaurine decreases by 80% when resting neutrophils are converted into actively respiring cells by exposure to opsonized zymosan. Hypotaurine activates hypoxia signaling through the competitive inhibition of prolyl hydroxylase domain-2. This leads to the activation of hypoxia signaling as well as to the enhancement of glioma cell proliferation and invasion.
Hypotaurine has antinociceptive effects on thermal, mechanical, and chemical nociception in the spinal cord. In CCI rats, hypotaurine alleviates mechanical allodynia and thermal hyperalgesia. Intrathecal hypotaurine suppresses acute, inflammatory, and neuropathic pain. Hypotaurine may regulate nociceptive transmission physiologically by activating glycinergic neurons in the spinal cord.
亚牛磺酸 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-01-25 | HY-100803 | 亚牛磺酸 | 300-84-5 | 50mg | 700 |
| 2024-01-25 | HY-100803 | 亚牛磺酸 | 300-84-5 | 10mM * 1mLin Water | 770 |
