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外観
無色透明の結晶又は白色の結晶性の粉末
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定義
本品は、酢酸(*)のナトリウム塩であり、次の化学式で表される。
参照表示名称：酢酸
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溶解性
無色澄明 (1.0g, 水20mL)水に極めて溶けやすく、エタノールにやや溶けやすい。
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用途
ニンヒドリン試液及び緩衝液調製用。
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用途
食品添加物。
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用途
医薬、製剤原料。
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用途
汎用試薬、合成原料、調製液及び緩衝液の調製原料。
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用途
酢酸ナトリウム(結晶)は食品添加物に使用されています。
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用途
窒素酸化物測定用試液調製用。
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化粧品の成分用途
緩衝剤、香料
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効能
透析液剤
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使用上の注意
温乾燥空気中で風解する。
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化学的特性
Sodium acetate trihydrate is the trihydrate sodium salt oaf acetic acid. It is a colorless, odorless crystals that can be weathered in the air. Soluble in water and ether, pH of 0.1M aqueous solution is 8.9. moderately soluble in ethanol, 5.3 g/100mL. Anhydrous Sodium acetate occurs as colorless, transparent crystals or a granular crystalline powder with a slight acetic acid odor.
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使用
Sodium acetate trihydrate is used in various applications. It is used as a buffer of a pH range in between to 4.0 to 6.0. It is also used in the purification and precipitation of nucleic acids and in protein crystallization. It is used as a mordant dyeing, as a pickling agent in chrome tanning, as a neutralizer in waste streams containing sulfuric acid, in the textile industry and as a photoresist while using aniline dyes. It plays an important role to retard vulcanization of chloroprene in synthetic rubber production. It is a precursor to prepare ester from alkyl halide. Other applications are in photography, as an additive to food, in purification of glucose, in preservation of meat, in tanning, and as a dehydrating agent. In analytical chemistry it is used to prepare buffer solution.
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製造方法
Sodium acetate is prepared by reacting sodium hydroxide or sodium carbonate with acetic acid in aqueous solution. The solution is evaporated to obtain hydrated crystals of sodium acetate.
NaOH + CH3COOH → CH3COONa + H2O
Na2CO3 + CH3COOH → 2CH3COONa + CO2 + H2O
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一般的な説明
Sodium acetate trihydrate can be obtained from the crystallization of sodium acetate in water. On heating at 75°C, it melts, while on heating above 120°C it loses water of crystallization and gets converted into anhydrous form. The hyperfine proton and 13C splittings have been evaluated by recording ESR spectra of its irradiated single crystals. ESR studies suggested the existence of trapped methyl radicals. Its crystals are monoclinic and its crystal structure has been investigated by photographic methods. Unit cell parameters were evaluated.
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応用例（製薬）
Sodium acetate is used as part of a buffer system when combined
with acetic acid in various intramuscular, intravenous, topical,
ophthalmic, nasal, oral, otic, and subcutaneous formulations. It may be used to reduce the bitterness of oral pharmaceuticals. It
can be used to enhance the antimicrobial properties of formulations;
it has been shown to inhibit the growth of S. aureus and E. coli, but
not C. albicans in protein hydrolysate solutions. It is widely used
in the food industry as a preservative. Sodium acetate has also
been used therapeutically for the treatment of metabolic acidosis in
premature infants, and in hemodialysis solutions.
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安全性
Sodium acetate is widely used in cosmetics, foods, and pharmaceutical
formulations, and is generally regarded as a
nontoxic and nonirritant material.
A short-term feeding study in chickens with a diet supplemented
with 5.44% sodium acetate showed reduced growth rates that were attributed to the sodium content.(9) Sodium acetate is poisonous if
injected intravenously, is moderately toxic by ingestion, and is an
irritant to the skin and eyes.
LD50 (rat, oral): 3.53 g/kg
LD50 (mouse, IV): 0.38 g/kg
LD50 (mouse, SC): 8.0 g/kg
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貯蔵
Sodium acetate should be stored in airtight containers.
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不和合性
Sodium acetate reacts with acidic and basic components. It will
react violently with fluorine, potassium nitrate, and diketene.
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規制状況(Regulatory Status)
GRAS listed. Accepted as a food additive in Europe. Included in the
FDA Inactive Ingredients Database (injections, nasal, otic, ophthalmic,
and oral preparations).
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参考文献
[1] http://www.europlat.org
[2] http://www.rxlist.com/sodium-acetate-drug.htm
[3] http://cosmetics.specialchem.com
[4] http://cecri.csircentral.net/2710/1/036-96.pdf
