KONGENSIN A
KONGENSIN A 性质
| 熔点 | 160-162 °C(Solv: chloroform (67-66-3)) |
|---|---|
| 沸点 | 525.7±50.0 °C(Predicted) |
| 密度 | 1.17±0.1 g/cm3(Predicted) |
| 储存条件 | 4°C, protect from light |
| 酸度系数(pKa) | 13.07±0.70(Predicted) |
KONGENSIN A 用途与合成方法
HSP90
RIP3
Apoptosis
Kongensin A (0-15 μM; 6 hours; HT29 cells) treatment induces caspase activation and apoptosis in multiple cancer cell lines in a dosage-dependent manner.
Kongensin A (0-15 μM; 24 hours; HT29 cells) treatment induces the degradation of RIPK1 and oncogenic kinases such as ERBB2, AKT, EGFR, and B-raf, and induces the up-regulation of HSP90A and HSP90B.
Kongensin A covalently binds to cysteine 420 in the middle domain of HSP90 and dissociates HSP90 from its cochaperone CDC37. The HSP90-CDC37 complex is required for RIP3 activation, KA blocks LPS/Smac mimetics/Z-VAD and RIP3 polymerization-induced cell death, in which cell death is dependent on RIP3 but not its upstream kinase RIP1.
Apoptosis Analysis
| Cell Line: | HT29 cells |
| Concentration: | 0 μM, 2.5 μM, 5 μM, 15 μM |
| Incubation Time: | 6 hours |
| Result: | Induced caspase activation and apoptosis in a dosage-dependent manner. |
Western Blot Analysis
| Cell Line: | HT29 cells |
| Concentration: | 0 μM, 2.5 μM, 5 μM, 15 μM |
| Incubation Time: | 24 hours |
| Result: | Induced the degradation of RIPK1 and oncogenic kinases such as ERBB2, AKT, EGFR, and B-raf, and induced the up-regulation of HSP90A and HSP90B. |
KONGENSIN A 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-01-25 | HY-N3417 | KONGENSIN A | 885315-96-8 | 1 mg | 9500 |
| 2023-03-20 | HY-N3417 | KONGENSIN A | 885315-96-8 | 5 mg | 20800 |
